Recyclable Polymerizable Deep Eutectic Solvent-Based 3D-Printed Dissolving Microneedles with pH-Responsive Delivery of ZIF-8-Loaded Minoxidil for Hair Loss Therapy

    Nail Aminov, Huan Liu, Decheng Meng, Liran Zhu, Xiaohan Guo, Cong Li, Xiaoqing Ye, Hui Li
    TLDR A new dissolving microneedle system effectively delivers minoxidil for hair regrowth with minimal side effects.
    The study presents a novel three-dimensional-printed dissolving microneedle (MN) system designed for the transdermal delivery of minoxidil (MXD) to treat hair loss. This system features a recyclable polymerizable deep eutectic solvent (PDES) base and pH-responsive tips loaded with MXD-encapsulated ZIF-8 nanoparticles. The MNs demonstrated excellent mechanical integrity, skin penetration, and minimal cytotoxicity. In vitro and in vivo tests, including a cyclophosphamide-induced alopecia mouse model, showed effective pH-triggered drug release and significant hair regrowth, with enhanced hair follicle density and minimal systemic toxicity. This innovative MN platform offers a promising and sustainable approach for hair loss therapy.
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