Recyclable Polymerizable Deep Eutectic Solvent-Based 3D-Printed Dissolving Microneedles with pH-Responsive Delivery of ZIF-8-Loaded Minoxidil for Hair Loss Therapy

    March 2026 in “ ACS Applied Materials & Interfaces ”
    Nail Aminov, Huan Liu, Decheng Meng … Hui Li
    Studysummary This study described a novel three-dimensional-printed microneedle system designed for improved transdermal delivery of minoxidil to treat hair loss, demonstrating effective hair regrowth and safety in a mouse model while allowing sustainable needle base recovery.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on pubs.acs.org →
    Discuss this study in the Community →

    Research cited in this study 19

    1. Microenvironment-Responsive Recombinant Collagen XVII-Based Composite Microneedles for the Treatment of Androgenetic Alopecia Acta Biomaterialia · 2025
    2. Hyaluronic Acid Microneedles Loaded With Chinese Herbal Extracts as an Intradermal Delivery System for Hair Regeneration Biomacromolecules · 2025
    3. Glutamic Acid-Loaded Separable Microneedle Composite for Long-Acting Hair Regeneration Treatment Advanced Composites and Hybrid Materials · 2025
    4. Efficacy, Safety, and Tolerability of Drugs for Alopecia: A Comprehensive Review Expert Opinion on Drug Metabolism & Toxicology · 2025
    5. Gas-Propelled Anti-Hair Follicle Aging Microneedle Patch for the Treatment of Androgenetic Alopecia Journal of Controlled Release · 2025
    6. One-Touch Embeddable Microneedles for Hair Loss Treatment International Journal of Pharmaceutics · 2024
    7. Dual-Continuous Microneedle Patch Integrating Transdermal Delivery of pH-Sensitive Licorzinc MOFs and Zn2+ Hydrogel Sensors for Treating Alopecia Areata Chemical Engineering Journal · 2024
    8. Rational Design of Human Hair Keratin-Driven Proteins for Hair Growth Promotion Advanced Healthcare Materials · 2024
    9. 3D Printed Microneedles: Revamping Transdermal Drug Delivery Systems Drug Delivery and Translational Research · 2024
    10. Temperature-Responsive Detachable Microneedles Integrated with Minoxidil Nanoparticle for Effectively Promoting Hair Regrowth Chemical Engineering Journal · 2024
    11. Effect of Microneedle on Hair Regrowth in Patients with Androgenetic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Chinese medicine and natural products · 2024
    12. Strontium Zinc Silicate Bioceramic Composite Electrospun Fiber Membrane for Hair Follicle Regeneration in Burn Wounds Composites Part B: Engineering · 2023
    13. Psychosocial Impact of Androgenetic Alopecia on Men: A Systematic Review and Meta-Analysis Psychology, Health & Medicine · 2023
    14. Drug Delivery Systems Based on Microneedles for Dermatological Diseases and Aesthetic Enhancement Current Medicinal Chemistry · 2023
    15. Dissolving Microneedle Patch Integrated With Microspheres For Long-Acting Hair Regrowth Therapy ACS Applied Materials & Interfaces · 2023
    16. Conditioned Media-Integrated Microneedles for Hair Regeneration Through Perifollicular Angiogenesis Journal of Controlled Release · 2022
    17. A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy Advanced healthcare materials/Advanced Healthcare Materials · 2022
    18. Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model Acta Biomaterialia · 2022
    19. Alginate-Based Hydrogel Containing Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex for Topical Alopecia Treatment Journal of Pharmaceutical Sciences · 2017