Ni–Cu Bimetallic Nanozyme and Minoxidil Co-Loaded Dissolving Microneedles Reshape Hair Follicle Microenvironment for Androgenic Alopecia Treatment

The study presents a novel treatment for androgenetic alopecia (AGA) using dissolvable microneedles co-loaded with nickel–copper nanozymes and minoxidil (NC&MXD MNs). This system enhances hair follicle microenvironment by scavenging reactive oxygen species and promoting angiogenesis through mechanostimulation. In AGA mouse models, the treatment improved hair regeneration coverage to 93.7% compared to 85.1% with minoxidil alone, increased cell proliferation by 1.9-fold, and thickened hair diameter. Additionally, it reduced ROS levels by 2.3-fold and increased vascular density by 40%, offering a safe, minimally invasive, and effective therapeutic approach for AGA.