Trilayer Dissolving Microneedle for Transdermal Delivery of Minoxidil: A Proof-of-Concept Study

    Nur Afika, Afifah Fadhilah Saniy, Athaullah Akmal Fawwaz Dharma, Christopher Kosasi Ko, Ruhi Kamran, Andi Dian Permana
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    TLDR The three-layer microneedle system effectively delivers minoxidil into the skin, showing potential as a safe and efficient treatment for hair loss.
    In a proof-of-concept study, a three-layer dissolving microneedle (TDMN) system was developed for the transdermal delivery of minoxidil (MNX), a treatment for alopecia areata (AA). This method aimed to improve drug penetration and reduce irritation compared to traditional oral and topical applications. The TDMN showed superior mechanical strength and was able to penetrate the stratum corneum. An ex-vivo permeation test revealed that TDMN2 had the highest average permeation of 165.28 ± 31.87 ug/cm2, significantly more than the 46.03 ± 8.5 ug/cm2 achieved by MNX cream. Additionally, in vivo dermatokinetic tests indicated that TDMN2 resulted in higher drug concentrations remaining in the skin than the cream. The TDMN formula was also found to be non-irritating and non-toxic based on HET-CAM and hemolysis tests, suggesting that TDMN could be an effective and safer alternative for AA treatment.
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