Trilayer Dissolving Microneedle for Transdermal Delivery of Minoxidil: A Proof-of-Concept Study

May 2024 in “ Journal of biomaterials science. Polymer ed. ”

Nur Afika, Afifah Fadhilah Saniy, Athaullah Akmal Fawwaz Dharma, Christopher Kosasi Ko, Ruhi Kamran, Andi Dian Permana

minoxidil alopecia areata trilayer dissolving microneedle transdermal delivery stratum corneum ex-vivo permeation test in vivo dermatokinetic tests HET-CAM test hemolysis test MNX AA TDMN

TLDR The three-layer microneedle system effectively delivers minoxidil into the skin, showing potential as a safe and efficient treatment for hair loss.

This study explored the use of three-layer dissolving microneedles (TDMN) for transdermal delivery of minoxidil (MNX) to treat alopecia areata (AA). The TDMN formulation aimed to enhance drug penetration and minimize irritation compared to traditional oral and topical methods. The TDMN2 formulation showed significantly higher drug permeation (165.28 ± 31.87 ug/cm²) compared to minoxidil cream (46.03 ± 8.5 ug/cm²). Ex vivo and in vivo tests confirmed higher drug retention in the skin with TDMN2, and safety tests indicated no irritation or toxicity. The study concludes that TDMN is a promising alternative for effective AA therapy.

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