3,3-Diphenylpentane Skeleton as a Steroid Skeleton Substitute: Novel Inhibitors of Human 5α-Reductase 1

    August 2007 in “ Bioorganic & medicinal chemistry letters ”
    Shinnosuke Hosoda, Yuichi Hashimoto
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    TLDR A new compound effectively inhibits human 5α-reductase 1.
    Researchers designed and synthesized new type 1 5α-reductase inhibitors using a 3,3-diphenylpentane skeleton instead of the traditional steroid skeleton. One of the compounds, 4-(3-(4-(N-Methylacetamido)phenyl)pentan-3-yl)phenyl dibenzylcarbamate (11k), was identified as a competitive inhibitor with an IC(50) value of 0.84 μM.
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