The review explores the pivotal role of the p63 gene in maintaining skin homeostasis and its involvement in skin diseases. It details the functions of its isoforms, TAp63 and ΔNp63, in regulating cell processes such as proliferation, differentiation, and stress responses. p63 is crucial for skin development, affecting epithelial fate, chromatin remodeling, cell adhesion, and barrier formation, and is involved in skin regeneration and differentiation through metabolic reprogramming and stem cell modulation. Mutations in p63 are associated with ectodermal dysplasia and other skin disorders, highlighting its significance in skin health. The review proposes that targeting p63 could offer therapeutic benefits for skin-related diseases.
12 citations
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October 2023 in “Tissue Engineering and Regenerative Medicine” 
54 citations
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October 2023 in “Oncogene” p63 is essential for controlling epithelial stem cells and tissue health.
2 citations
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May 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” A TP63 gene mutation causes significant hair loss and mild skin, nail, and tooth abnormalities.
19 citations
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September 2019 in “PLOS genetics” Telomere damage affects skin and hair follicle stem cells by messing up important growth signals.
29 citations
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October 2016 in “Cell death and differentiation” ΔNp63α stops TAp73β from working in skin cancer by blocking its access to specific genes, not by directly interacting with it.
46 citations
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July 2015 in “Wound repair and regeneration” Keloid scars may form due to changes in skin cell characteristics and specific protein signaling.
1235 citations
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December 2013 in “Nature” Two fibroblast types shape skin structure and repair differently.
166 citations
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September 2011 in “The Journal of Cell Biology” p63 controls Satb1 to help skin develop properly.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
54 citations
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October 2023 in “Oncogene” p63 is essential for controlling epithelial stem cells and tissue health.
11 citations
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November 2015 in “Experimental Dermatology” The conclusion is that the IL-6/STAT3 activation affects p63 expression in healing wounds, which may help in hair follicle regeneration.
2 citations
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May 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” A TP63 gene mutation causes significant hair loss and mild skin, nail, and tooth abnormalities.
15 citations
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July 2024 in “Current Issues in Molecular Biology” Understanding molecular processes in skin development is key to creating targeted treatments for skin disorders.
