The Effects of Photobiomodulation on MC3T3-E1 Cells via 630 nm and 810 nm Light-Emitting Diode

November 2019 in “ Medical Science Monitor ”

Biao Chang, Haixia Qiu, Hongyou Zhao, Xi Yang, Ying Wang, Tengda Ji, Yuxuan Zhang, Qi Quan, Yunqi Li, Jing Zeng, Haoye Meng, Ying Gu

TLDR LED light therapy boosts bone cell growth and function.

The study investigated the effects of photobiomodulation (PBM) using 630 nm and 810 nm light-emitting diodes (LEDs) on MC3T3-E1 osteoblast cells. The results demonstrated that LED PBM enhanced cell proliferation, reduced apoptosis, and increased alkaline phosphatase (ALP) staining intensity and activity. Additionally, there was a significant enhancement in mineralization and increased mRNA expression of osteocalcin (OCN) and osteoprotegerin (OPG) in the irradiated groups compared to non-irradiated controls. The study concluded that LED PBM could effectively promote osteoblast cell growth and function, with no significant difference observed between the effects of 630 nm and 810 nm wavelengths.

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