Red LED Photobiomodulation Enhances Metabolic Activity in Cultured Human Pericytes

    January 2026 in “ Journal of Hard Tissue Biology ”
    Yuki Ito, Yoshihiko Sugita, Kei Kamiya, Yoshitaka Nagaya, Tomofumi Hattori, Masanori Nagasawa, Ryoko Kawai, Ms. Waka Yoshida, Katsutoshi Kubo, Hatsuhiko Maeda
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    Studysummary This study found that red LED photobiomodulation significantly enhanced both the metabolic activity and proliferation of human placenta-derived pericytes, alongside increased expression of angiogenic markers, suggesting a potential non-invasive approach to aid tissue repair and vascular regeneration.
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    Red LED photobiomodulation (PBM) at 655 nm significantly enhances metabolic activity and proliferation in cultured human pericytes, as demonstrated by increased cell proliferation and upregulation of angiogenesis-related markers (Ang-1, CD146, PDGFR-β, VEGF-A) at 3, 6, and 24 hours post-irradiation. The study found no temperature elevation during LED exposure, indicating a safe application. These findings suggest that red LED PBM could be a promising non-invasive strategy for promoting wound healing and vascular regeneration by activating pericytes.
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