Irradiation by High-Intensity Red LED Enhances Human Bone Marrow Mesenchymal Stem Cells Osteogenic Differentiation and Mineralization Through Wnt/β-Catenin Signaling Pathway

This study investigated the effects of high-intensity red LED irradiation on human bone marrow mesenchymal stem cells (BMSCs), focusing on osteogenic differentiation and mineralization through the Wnt/β-catenin signaling pathway. The study found that while BMSC proliferation was not affected after 72 hours, a 30-second exposure to 6 J/cm² significantly enhanced osteogenic differentiation and mineralization. This enhancement was linked to the activation of the Wnt/β-catenin pathway, as it was suppressed by the inhibitor XAV939. The findings suggested that short-duration irradiation with a high-intensity red LED could be a potential method for promoting hard tissue regeneration.