P140 Light-Emitting Diode Light Regulates the Proliferation of Human Outer Root Sheath Cells via Wnt/β-Catenin and ERK Pathway
January 2016
in “
프로그램북(구 초록집)
”
LED light human outer root sheath cells hORSCs Wnt/β-catenin pathway ERK pathway Wnt5a Axin2 Lef1 mRNA β-catenin protein phosphorylation of ERK c-Jun p38 red light treatment IL-6 IL-8 IGF-1 TGF-β1 VEGF mRNA human dermal papilla cells hDPCs outer root sheath cells Wnt pathway red light interleukin-6 interleukin-8 insulin-like growth factor 1 transforming growth factor beta 1 vascular endothelial growth factor dermal papilla cells
TLDR LED light promotes hair growth by stimulating cell proliferation and reducing cell death.
The study investigated the effects of various wavelengths of LED light on human outer root sheath cells (hORSCs). It was found that low-level LED irradiation promoted hORSC proliferation, suppressed apoptosis, and enhanced migration. This effect was linked to the activation of Wnt/β-catenin and ERK signaling pathways, as evidenced by increased expression of Wnt5a, Axin2, Lef1 mRNA, and β-catenin protein, along with phosphorylation of ERK, c-Jun, and p38. Additionally, red light treatment upregulated IL-6, IL-8, IGF-1, TGF-β1, and VEGF mRNA expressions. LED-irradiated hORSCs also boosted the proliferation of human dermal papilla cells (hDPCs) in co-culture, suggesting that LED light promotes hair growth through these molecular pathways.
