A NIR-Responsive PDA@RES Core-Shell Nanoplatform Accelerates Chronic Wound Healing by Remodeling Mitochondrial Homeostasis and Reversing Cellular Senescence

February 2026 in “ Nano Research ”

Jian Feng, Huixin Lv, Siyu Chen, Yuemeng Zhu, Yuzhu Han, Mucong Li, Jingxia Chen, Jiaxin Luo, Dixin He, Yidi Zhang, Yanmin Zhou

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polydopamine resveratrol NIR-responsive photothermal therapy reactive oxygen species mitochondrial dysfunction cellular senescence AMPK/PGC-1α signaling pathway mitophagy mitochondrial biogenesis macrophage phenotype collagen deposition vascular regeneration hair follicle structures PDA RES near-infrared ROS AMPK PGC-1α

Studysummary In this study, researchers developed a near-infrared-responsive nanoplatform that synergistically enhances chronic wound healing by accelerating mitochondrial restoration and immune modulation, leading to enhanced wound repair and high-quality healing in diabetic rat models.

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