A Novel In Vivo Active Pemphigus Model Targeting Desmoglein 1 and Desmoglein 3: A Tool Representing All Pemphigus Variants
May 2023
in “
Biology
”
TLDR New mouse models of Pemphigus show severe symptoms and need better treatments.
The study developed new active mouse models of Pemphigus targeting Desmoglein 1 (DSG1) and both Desmoglein 1 and 3 (DSG1/DSG3) to mimic Pemphigus Foliaceous and mucocutaneous Pemphigus, respectively. These models successfully produced high concentrations of specific autoantibodies and exhibited severe disease symptoms, including alopecia, skin erosions, and blistering. Mucosal lesions were observed in DSG3 and DSG1/DSG3 models. The corticosteroid Methyl-Prednisolone showed only partial effectiveness in treating these models, highlighting the need for better therapeutic strategies.
