A Novel In Vivo Active Pemphigus Model Targeting Desmoglein 1 and Desmoglein 3: A Tool Representing All Pemphigus Variants
May 2023
in “
Biology
”
TLDR New mouse models of Pemphigus show severe symptoms and need better treatments.
The study developed a novel in vivo pemphigus model targeting Desmoglein1 (DSG1) and Desmoglein3 (DSG3) in mice, successfully representing all pemphigus variants, including Pemphigus Vulgaris (PV), Pemphigus Foliaceous (PF), and mucocutaneous pemphigus. The model showed high antibody production, severe symptoms, and distinct histologic patterns of cell adhesion loss. Methyl-Prednisolone treatment was partially effective. This model is valuable for studying disease mechanisms, evaluating therapies, and understanding long-term disease processes, despite being complex and time-consuming to set up.
