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GlossaryDesmoglein 3

protein crucial for cell adhesion in skin and mucous membranes

Desmoglein 3 (Dsg3) is a protein that plays a crucial role in cell adhesion, specifically in the skin and mucous membranes. It is a component of desmosomes, which are structures that help cells stick together, providing strength and integrity to tissues. Defects or autoimmune attacks against Dsg3 can lead to conditions like pemphigus vulgaris, a disease characterized by blistering and erosion of the skin and mucous membranes.

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research Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature

15 citations, June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mice with extra human KLK14 had hair and skin problems, including weaker cell bonds and inflammation, linked to Netherton syndrome.

research A Novel Animal Model of Desmoglein 1 (Dsg1) Deficiency Reveals an Essential Role for Dsg1 in Epidermal Barrier Formation

April 2018 in “Journal of Investigative Dermatology”

Dsg1 is essential for maintaining a healthy skin barrier in mice.

research Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-Epithelialization

28 citations, March 2017 in “Endocrinology”

Removing vitamin D and calcium receptors in mice skin cells slows down skin wound healing.

research SnapshotDx Quiz: November 2017

October 2017 in “Journal of Investigative Dermatology”

Pemphigus vulgaris involves specific immune cells and B cells that produce antibodies causing skin blisters.

research Scalp Involvement in Pemphigus: A Prognostic Marker

10 citations, November 2017 in “Advances in Dermatology and Allergology”

Scalp involvement in pemphigus means the disease is more severe and harder to treat.

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