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    Glossary Desmoglein 3

    protein crucial for cell adhesion in skin and mucous membranes

    Desmoglein 3 (Dsg3) is a protein that plays a crucial role in cell adhesion, specifically in the skin and mucous membranes. It is a component of desmosomes, which are structures that help cells stick together, providing strength and integrity to tissues. Defects or autoimmune attacks against Dsg3 can lead to conditions like pemphigus vulgaris, a disease characterized by blistering and erosion of the skin and mucous membranes.

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    Research 30 of 398

    1. Expression of Desmoglein 1 Compensates for Genetic Loss of Desmoglein 3 in Keratinocyte Adhesion Journal of Investigative Dermatology · 2002 · 72 citations
    2. Differential structural properties and expression patterns suggest functional significance for multiple mouse desmoglein 1 isoforms Differentiation · 2004 · 29 citations
    3. Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris Journal of Dermatological Science · 2011 · 17 citations
    4. Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature 2020 · 15 citations
    5. 875 A novel animal model of Desmoglein 1 (Dsg1) deficiency reveals an essential role for Dsg1 in epidermal barrier formation Journal of Investigative Dermatology · 2018
    6. Localized Hypotrichosis Type 1 Due to Intragenic Deletion of Exons 5-8 in Desmoglein Gene in a Neonate from Indian Family Acta Scientific Paediatrics · 2023
    7. Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity Nature Genetics · 2004 · 372 citations
    8. A Novel In Vivo Active Pemphigus Model Targeting Desmoglein1 and Desmoglein3: A Tool Representing All Pemphigus Variants Biology · 2023 · 2 citations
    9. 1422 Uncoupling desmosomal cadherin adhesion activates quiescent hair follicle stem cells and orchestrates self-organized regeneration through outside-in signaling Journal of Investigative Dermatology · 2023
    10. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    11. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization Endocrinology · 2017 · 28 citations
    12. Identification of Differentially Expressed Genes During a Wool Follicle Growth Cycle Induced by Prolactin Journal of Investigative Dermatology · 1999 · 26 citations
    13. LEKTI: Netherton Syndrome and Atopic Dermatitis InTech eBooks · 2013 · 1 citations
    14. In pemphigus, cell detachment, but not autoantibody binding, induces cell-wide, long-lasting transcriptomic and proteomic changes bioRxiv (Cold Spring Harbor Laboratory) · 2025
    15. SnapshotDx Quiz: November 2017 Journal of Investigative Dermatology · 2017
    16. In this Issue Journal of Investigative Dermatology · 2002
    17. The role of natural killer cells in autoimmune blistering diseases Autoimmunity · 2011 · 24 citations
    18. Genetics of Alopecia Encyclopedia of Life Sciences · 2012
    19. Stem Cells and their Niches Journal of Investigative Dermatology · 2013 · 1 citations
    20. Scalp involvement in pemphigus: a prognostic marker Advances in Dermatology and Allergology · 2017 · 10 citations
    21. Increased risk of severe course of pemphigus in patients with pemphigus‐associated alopecia: a prospective observational study Clinical and Experimental Dermatology · 2018 · 2 citations
    22. Molecular biology of hair morphogenesis: Development and cycling Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution · 2003 · 155 citations
    23. Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity Developmental Biology · 2008 · 28 citations
    24. Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation Theranostics · 2021 · 18 citations
    25. Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three‐dimensional skin equivalent model <i>in vitro</i>: implications for regenerative therapy of canine epidermis Veterinary dermatology · 2013 · 11 citations
    26. Pemphigus Vulgaris IgG and Methylprednisolone Exhibit Reciprocal Effects on Keratinocytes Journal of Biological Chemistry · 2004 · 99 citations
    27. Vesicle Formation and Follicular Root Sheath Separation in Mice Homozygous for Deleterious Alleles at the Balding (bal) Locus 1997 · 38 citations
    28. A case of monilethrix caused by novel compound heterozygous mutations in the desmoglein 4 (DSG4) gene British Journal of Dermatology · 2011 · 26 citations
    29. Alopecia as a rare but distinct manifestation of pemphigus vulgaris Journal of the European Academy of Dermatology and Venereology · 2011 · 23 citations
    30. Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation Molecular and cellular biology · 2002 · 108 citations