SnapshotDx Quiz: November 2017
October 2017
in “
Journal of Investigative Dermatology
”
Studysummary This article presents a diagnostic quiz based on clinical images and reports findings from the mentioned article but does not provide new clinical results.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The "SnapshotDx Quiz: November 2017" from the Journal of Investigative Dermatology focused on diagnosing pemphigus vulgaris (PV), an autoimmune disease with IgG autoantibodies against Desmoglein 3 and 1, causing intraepidermal blisters. The quiz clarified differences between PV and other similar conditions and highlighted the association of paraneoplastic pemphigus with certain cancers. Yuan et al.'s article discussed the presence of desmoglein-specific B-cells and increased CCL19 expression in PV lesions, indicating its role in lymphocyte aggregation. The study found that PV lesions contained various immune cells, including CD3+, CD4+ T cells, CD19+ B cells, and CD138+ plasma cells, with a higher frequency of desmoglein-specific B cells and CD4+IL-21+ T-cells compared to healthy skin. The findings supported the role of B cells in antibody secretion in PV.
