SnapshotDx Quiz: November 2017

October 2017 in “ Journal of Investigative Dermatology ”

Shailee Patel, Mariya Miteva

pemphigus vulgaris IgG autoantibodies Desmoglein 3 Desmoglein 1 intraepidermal blisters paraneoplastic pemphigus desmoglein-specific B-cells CCL19 CD3+ T cells CD4+ T cells CD19+ B cells CD138+ plasma cells CD4+IL-21+ T-cells

TLDR Pemphigus vulgaris involves specific immune cells and B cells that produce antibodies causing skin blisters.

The "SnapshotDx Quiz: November 2017" from the Journal of Investigative Dermatology focused on diagnosing pemphigus vulgaris (PV), an autoimmune disease with IgG autoantibodies against Desmoglein 3 and 1, causing intraepidermal blisters. The quiz clarified differences between PV and other similar conditions and highlighted the association of paraneoplastic pemphigus with certain cancers. Yuan et al.'s article discussed the presence of desmoglein-specific B-cells and increased CCL19 expression in PV lesions, indicating its role in lymphocyte aggregation. The study found that PV lesions contained various immune cells, including CD3+, CD4+ T cells, CD19+ B cells, and CD138+ plasma cells, with a higher frequency of desmoglein-specific B cells and CD4+IL-21+ T-cells compared to healthy skin. The findings supported the role of B cells in antibody secretion in PV.