Pharmacodynamics and Pharmacokinetics of P-3074, a New Finasteride Topical Solution, Administered at Four Different Doses
January 2014
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary P-3074 effectively blocks scalp DHT better than oral finasteride.
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The study investigated the pharmacodynamics and pharmacokinetics of P-3074, a new topical finasteride solution, in 32 men aged 18-65 with androgenetic alopecia. Participants were divided into four cohorts, each receiving different doses of the solution or a placebo for 7 days. The study aimed to determine the effective dose of topical finasteride at the hair bulb level while minimizing adverse effects associated with oral finasteride. Results showed that P-3074 effectively penetrated the scalp and blocked local DHT more consistently than oral finasteride. The study was conducted in Switzerland and funded by Polichem SA. Potential risks included known adverse reactions to finasteride, but no significant benefits were anticipated for participants.
