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    Glossary oncogene

    gene that can cause cancer when mutated or overexpressed

    An oncogene is a type of gene that, when mutated or expressed at high levels, can transform a normal cell into a cancerous one. In simpler terms, it's like a switch that, when turned on incorrectly, can lead to uncontrolled cell growth and potentially cancer. For professionals, oncogenes are often derived from proto-oncogenes, which are normal genes involved in cell growth and division, but become harmful when altered.

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    Research 30 of 1000+

    1. Acute sensitivity of the oral mucosa to oncogenic <i>K‐ras</i> Journal of pathology · 2011 · 12 citations
    2. Differential metabolic adaptations define responses of winner and loser oncogenic mutant stem cells in skin epidermis<i>in vivo</i> bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 2 citations
    3. Oncogenes and morphogens: intricacies of targeted therapy in cutaneous basal cell carcinoma British Journal of Dermatology · 2017
    4. Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation bioRxiv (Cold Spring Harbor Laboratory) · 2022
    5. LB1011 Oncogenic ras mutation induces spatiotemporally specific tissue deformation through converting fluctuated into sustained ERK activation Journal of Investigative Dermatology · 2022
    6. Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice Oncogene · 1999 · 150 citations
    7. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    8. Ontogenetic Transition in Fetal Wound Transforming Growth Factor-β Regulation Correlates with Collagen Organization American Journal of Pathology · 2003 · 109 citations
    9. A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease Nature Communications · 2019 · 67 citations
    10. Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation Nature Cell Biology · 2024 · 19 citations
    11. Hair follicle regeneration suppresses Ras-driven oncogenic growth Journal of Cell Biology · 2019 · 17 citations
    12. The HPV16 oncogenes cause aberrant stem cell mobilization Virology · 2013 · 23 citations
    13. Expression of E6 and E7 papillomavirus oncogenes in the outer root sheath of hair follicles extends the growth phase and bypasses resting at telogen. PubMed · 2000 · 10 citations
    14. Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation BMC Cancer · 2011 · 7 citations
    15. Severe follicular hyperplasia and spontaneous papilloma formation in transgenic mice expressing theneu oncogene under the control of the bovine keratin 5 promoter Molecular Carcinogenesis · 1998 · 47 citations
    16. Author response: Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma 2021
    17. Decision letter: Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma 2021
    18. Author response: Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium 2020
    19. Decision letter: Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium 2020
    20. Molecular mechanisms of viral oncogenesis in humans Nature Reviews Microbiology · 2018 · 141 citations
    21. Human Papillomavirus E6/E7 Oncogenes Promote Mouse Ear Regeneration by Increasing the Rate of Wound Re-epithelization and Epidermal Growth Journal of Investigative Dermatology · 2008 · 19 citations
    22. The E6/E7 oncogenes of human papilloma virus and estradiol regulate hedgehog signaling activity in a murine model of cervical cancer Experimental Cell Research · 2019 · 9 citations
    23. Iperplasia Collaterale Nella Oncogenesi Sperimentale Del Ratto: Rilievi in corso di trattamento con Vitamina A Tumori Journal · 1961
    24. Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. PubMed · 2003 · 114 citations
    25. Editor's evaluation: Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma 2021
    26. Abstract 1835: Development of mammary hyperplasia, dysplasia, and invasive ductal carcinoma in transgenic mice expressing the 8p11 amplicon oncogene NSD3 (WHSC1L1) Cancer Research · 2017 · 1 citations
    27. Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells iScience · 2021 · 5 citations
    28. Expression of hair keratins in the adult nail unit: an immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed British Journal of Dermatology · 2004 · 110 citations
    29. Recent Advances in Genetically Engineered Mouse Models of Melanoma: Insights into Tumor Initiation and Oncogenic Signaling Pathways International Journal of Stem Cells · 2026
    30. Skin Cancer: Mechanisms and Human Relevance Medical Entomology and Zoology · 1994 · 213 citations