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This study demonstrates that YAP and TAZ are essential for initiating basal and squamous cell carcinomas in mice, and suggests targeting these pathways could be beneficial for treating skin cancers.

This study reports that transgenic mice carrying Clone B DNA developed spontaneous melanomas likely due to an interruption in genes regulating cell growth in melanin-producing cells, offering a model for melanoma research.

This review highlights the potential of in vivo reprogramming using OSKM transcription factors for developing rejuvenating and regenerative strategies, while noting the associated risk of tumorigenicity and discussing how improved understanding could lead to safer applications.

In this study, researchers found that a subset of mammary cells with active Wnt signaling in mice does not develop tumors upon ErbB2 activation and instead undergoes apoptosis, potentially protecting against carcinogenesis.

This article reviews the role of KLF4, a transcription factor, in various cellular processes and its dual function as a tumor suppressor or oncogene depending on the context, but presents no new experimental results.

This study found that NKIRAS2 expression affects skin tumor suppression and HRAS-driven transformation in mice, indicating its role in carcinogenesis depends on expression level and cellular context.

Complex basal cell carcinomas need personalized treatment due to unique genetic mutations.

This study suggests that the oncogene c-Myc can induce DNA damage by increasing reactive oxygen species, potentially overriding p53 and contributing to genetic instability in cancer cells.

This study found that in mice, type XVII collagen is essential for controlling epidermal cell proliferation through Wnt signaling, with its deficiency or altered distribution leading to skin hyperproliferation and aging-like changes.

This study found that type XVII collagen (COL17) regulates interfollicular epidermis proliferation in both neonatal and aged mice through Wnt signaling, suggesting its potential as a target for anti-aging skin strategies.

This study found that type XVII collagen is crucial for regulating epidermal cells' proliferation in mice and may be a promising target for anti-aging skin treatments.

Fgfr2b helps maintain healthy skin and prevent cancer.

In this study, researchers demonstrated that the expression of the oncogene SmoM2 leads to basal cell carcinoma in the ear epidermis of mice but not in the back skin, with differences in susceptibility linked to the composition of the extracellular matrix.

This study in engineered mouse models suggests that some basal cell carcinomas may originate from hair follicle tissue stem cells upon leaving their stem cell niche.

This study explored the immune environment of the hair follicle's bulge region and suggested that its unique signaling may prevent melanoma formation by lacking necessary proinflammatory signals for full oncogenic transformation, indicating potential strategies for melanoma prevention by replicating this immune-privileged environment.

This study found that a catalytically active version of Vav2 significantly altered gene expression patterns in hair follicle stem cells in mice, with these changes varying over the animals' lifespans.

Senescent melanocytes in nevus skin boost hair growth.

This study observed that nevus melanocytes do not exhibit signs of senescence, suggesting that their growth arrest is due to cell interactions and not directly caused by BRAF activation.

This study suggests that the growth arrest of nevus melanocytes is not due to oncogene-induced senescence but rather to collective cell interactions, similar to those in normal tissue size regulation.

This review discusses cellular plasticity in skin and intestine, hypothesizing that mature cell reprogramming might contribute to tumorigenesis, and reports no new clinical results.

This study reports a new family with hereditary fibrosing poikiloderma (POIKTMP) and identifies a pancreatic cancer occurrence in a family member, raising questions about FAM111B's role as a potential cancer predisposition gene.

This review discusses stem cell behavior, highlighting their plasticity in tissue repair and the impact of somatic mutations on clonal expansion in early cancer, but reports no new experimental results.

This review discusses the potential role of FGF5 as a therapeutic target in prostate cancer and other conditions but reports no new results, highlighting a need for further research on FGF5 inhibitors.

This review describes oncotherapy-induced alopecia in patients receiving hormone therapy for hormone-receptor-positive breast cancer and concludes that topical hormones should not be used due to oncogenic potential.

This article discusses the impact of the tabby mutation on secondary vibrissae and hair follicle patterns in mice and reports no new clinical results.

This review discusses the characteristics and potential applications of epidermal stem cells in dermatology, without providing new clinical results.

This study suggests that hair follicle stem cells have a unique metabolic profile that may play a critical role in their maintenance and response to cancer-related changes, potentially contributing to the "Warburg Effect.

This review outlines the advancements in organ and tissue transplantation since the discovery of the human MHC and reports no new clinical results.

This review examines cell senescence pathways in melanocytes, highlighting the involvement of telomere attrition, the p16/RB pathway, and cAMP signaling in the context of melanoma development, but reports no new findings.

This review summarizes current evidence on how beta-human papillomavirus and Merkel cell polyomavirus may contribute to the development of nonmelanoma and Merkel cell skin carcinomas, respectively, but it reports no new clinical findings.