Collateral Hyperplasia in Experimental Rat Oncogenesis: Observations During Vitamin A Treatment

In a study involving 33 rats inoculated with 10 mg of 3,4-benzpyrene, 18 rats were treated with 1000 I.U. of vitamin A weekly. The treatment resulted in a reduction of hyperplastic-dysplastic phenomena and hair hypoplasia and hypotrophy, particularly in the skin overlying the tumor. Additionally, there was a moderate reduction in epidermal activity, a marked decrease in hyperplasia and hypertrophy of sebaceous glands, and increased fibrillogenesis in the tumor capsule compared to untreated controls.