Abstract 1835: Development of Mammary Hyperplasia, Dysplasia, and Invasive Ductal Carcinoma in Transgenic Mice Expressing the 8p11 Amplicon Oncogene NSD3 (WHSC1L1)

    July 2017 in “ Cancer Research ”
    Alex Rutkovsky, Brittany Turner-Ivey, Ericka L. Smith, Laura Spruill, Jamie N. Mills, Stephen P. Ethier
    TLDR Overexpressing NSD3 in mice causes breast cancer-like tumors and gland abnormalities.
    The study investigated the role of the NSD3 oncogene in breast cancer by using transgenic mice with overexpression of NSD3 in the mammary gland. The results showed that these mice experienced significant mammary gland abnormalities, including increased branching, terminal bud formation, and alveolar hyperplasia. The transgenic mice also developed palpable tumors by 40 weeks of age, which were similar to human breast cancer patterns such as micropapillary and cribriform ductal carcinoma in situ. The study concluded that NSD3 overexpression led to mammary gland deformation, inhibited functional differentiation, and caused tumor formation, highlighting the oncogenic potential of NSD3 in breast cancer. Further research on this model and NSD3's role could improve outcomes for patients with 8p11-12 altered cancers.
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