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This study found that coactivating LIN28B and follistatin enhances cochlear supporting cells' ability to regenerate hair cells in neonatal mice by reprogramming them into progenitor-like cells.

This review discusses how engineering cell surfaces with polyelectrolytes can address challenges in cell therapy and related biomedical fields and reports no new research findings.

This study suggests that cancer risk may be influenced by the balance of pro- and anti-oncogenic mutants in normal tissues rather than by the total number of mutations.

This review examines the complex mechanisms that regulate skin stem cell development, activation, and differentiation, emphasizing the molecular signaling pathways that influence their fate and contribute to skin homeostasis.

This review summarizes the roles of various cells and signaling pathways in skin wound healing, highlights deviations leading to pathological outcomes like chronic wounds, and evaluates cutting-edge approaches such as biomaterials and precision medicine to improve healing and intervention strategies.

This study found that 3D-cultured dermal papilla cells more accurately mimic in vivo conditions compared to 2D cultures, enhancing our understanding of molecular mechanisms in androgen-induced alopecia.

This study found that the MIR34A rs2666433 (A/G) variant is linked to increased risk and severity of alopecia areata, and high circulatory miR-34a levels may play a role in the disease's pathogenesis.

This study found that Aire‒/‒ mice spontaneously developed persistent AA-like lesions, highlighting a potential role for AIRE in hair follicle biology and pathogenesis of alopecia areata.

This study found that mouse astrocytes formed cell spheres on agarose surfaces, acquired stem cell-like features, and their derived stem cells effectively differentiated into neurons that helped regenerate damaged nerves.

This review explores emerging therapies for hair regrowth, highlighting two strategies: hair follicle neogenesis and Wnt/B-catenin pathway modulation, which show promise for treating alopecia by potentially offering more effective options than existing treatments.

This study reviews the role of skin stem cells in aging and explores how organoids, as opposed to traditional methods, can advance research into aging skin and regenerative therapies.

This study identified core genes and pathways involved in androgenetic alopecia, finding that genes related to hair follicle development are down-regulated, while those linked to immune responses are up-regulated, highlighting potential therapeutic targets.

New inhibitors may help treat hair loss by promoting fat cell growth in the skin.

This study found that the transcription factor Gata6 regulates the sebaceous duct lineage identity and plays a crucial role in epidermal wound healing by enabling dedifferentiation and broader lineage capabilities in post-mitotic cells.

This study highlights the crucial, multifaceted roles of fibroblasts in wound healing and various diseases, including their dysregulation in diabetic foot ulcers, underscoring the need for targeted therapies to address complications and morbidity from such chronic conditions.

This study found that large excisional wounds in rats across seven strains do not regenerate new hair follicles, unlike in mice, possibly due to differences in epidermal competence and transcriptional profiles.

This study found that Alpinetin, applied topically in C57BL/6J mice, promoted hair regeneration by activating hair follicle stem cells through Wnt signaling, extending the anagen phase and increasing hair shaft length, with no cytotoxicity observed in keratinocytes and fibroblasts.

Skin organoids can mimic human skin responses to injury and inflammation, making them useful for studying skin diseases and testing treatments.

This review discusses the role of mTOR kinase in pulmonary fibrosis and explores how mTOR inhibitors may help slow the progression of this condition, but it reports no new results.

This review summarizes recent progress in microneedle-based drug delivery systems and discusses their potential impact on cellular mechanisms and immunization signaling pathways, highlighting the need for further development in fabrication methods.

Stress can cause hair loss and skin issues by affecting hair growth cycles.

This review discusses the integration of biodegradable biomaterials with drugs and stem cells for diabetic wound repair, but reports no new clinical results and highlights the need for further translation to clinical practice.

This review focuses on the role of the transcription factor Foxn1 in skin biology and discusses its potential implications for regenerative medicine, but reports no new clinical results.

In this study, targeted inactivation of the integrin-linked kinase gene in melanoblasts led to defects in cell migration, proliferation, and ability to populate the skin, implicating an integrin-linked kinase-Rac1 connection in melanocyte function.

This study suggests that distinct chromatin topologies allow different lineage-specific enhancers to regulate Hoxd genes in mouse vibrissae and chicken feather primordia, while conserved regulatory elements maintain transcriptional robustness in the embryonic trunk across species.

In this study, around 1% of proteins in skin fibroblasts significantly changed in response to reductive stress, affecting collagens and MAPK signaling pathways.

This review discusses the role of Wnt signaling in cardiac development and explores attempts to modulate it for improving heart function after ischemic injury, but reports no new experimental results.

This review discusses the benefits of β-sitosterol, a plant compound found in nuts and seeds, which may lower "bad" cholesterol and help prevent heart disease, cancer, and diabetes, but notes the lack of clinical studies on its safety and effectiveness in humans.

This review discusses the formation and maintenance of hair follicles through dynamic cellular changes and signaling pathways, presenting a comprehensive overview but providing no new experimental findings.

This review discusses the biological characteristics and potential of epidermal stem cells in orthopedic regenerative medicine but reports no new experimental findings.