Somatic Mutations in Normal Tissues: New Perspectives on Early Carcinogenesis

    January 2023 in “ Annual Review of Cancer Biology ”
    Albert Herms, Philip H. Jones
    Studysummary This study suggests that cancer risk may be influenced by the balance of pro- and anti-oncogenic mutants in normal tissues rather than by the total number of mutations.
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    Research cited in this study 3

    1. Injury Suppresses Ras Cell Competitive Advantage Through Enhanced Wild-Type Cell Proliferation bioRxiv (Cold Spring Harbor Laboratory) · 2022
    2. Hair Follicle Regeneration Suppresses Ras-Driven Oncogenic Growth Journal of Cell Biology · 2019
    3. Switching Roles: The Functional Plasticity of Adult Tissue Stem Cells The EMBO Journal · 2015