Injury Suppresses Ras Cell Competitive Advantage Through Enhanced Wild-Type Cell Proliferation

January 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Sara Gallini, Nur-Taz Rahman, Karl Annusver, David G. Gonzalez, Sangwon Yun, Catherine Matte-Martone, Tianchi Xin, Elizabeth Lathrop, Kathleen C. Suozzi, Maria Kasper, Valentina Greco

Ras mutant cells Hras G12V Kras G12D wild-type cells EGFR inhibition cell cycle inhibitor p21 skin epithelium

Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

Studysummary This study found that injury-induced proliferation of wild-type cells can suppress oncogenic growth in Ras-mosaic skin.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research The Malignant Capacity of Skin Tumors Induced by Expression of a Mutant H-Ras Transgene Depends on the Cell Type Targeted

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