Developmental and Evolutionary Comparative Analysis of a Regulatory Landscape in Mouse and Chicken

    June 2022 in “ Development ”
    Aurélie Hintermann, Isabel Guerreiro, Lucille Lopez‐Delisle … Leonardo Beccari
    Studysummary This study suggests that distinct chromatin topologies allow different lineage-specific enhancers to regulate Hoxd genes in mouse vibrissae and chicken feather primordia, while conserved regulatory elements maintain transcriptional robustness in the embryonic trunk across species.
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    Research cited in this study 6

    1. Mammalian-Specific Ectodermal Enhancers Control the Expression of Hoxc Genes in Developing Nails and Hair Follicles Proceedings of the National Academy of Sciences · 2020
    2. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Cell Stem Cell · 2018
    3. Getting to the Root of Scales, Feathers, and Hair: As Deep as Odontodes? Experimental Dermatology · 2017
    4. Early Inductive Events in Ectodermal Appendage Morphogenesis Seminars in cell & developmental biology · 2014
    5. Genetic Basis of Skin Appendage Development Seminars in cell & developmental biology · 2007
    6. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998