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GlossaryMyc Family

group of genes crucial for cell growth and division

The Myc Family refers to a group of genes that play a crucial role in cell growth, division, and differentiation. These genes, including c-Myc, N-Myc, and L-Myc, are often implicated in cancer because their overexpression can lead to uncontrolled cell proliferation.

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research Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle

45 citations , April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.

research Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration

21 citations , June 2016 in “PloS one”

Zebrafish need MYC and FGF to regenerate inner ear hair cells.

Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (<i>Hr<sup>rh-R</sup></i>) in the Hairless Gene (<i>Hr</i>)

research Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr^rh-R) in the Hairless Gene (Hr)

10 citations , January 2010 in “Veterinary pathology”

A new mutation in the hairless gene causes hair loss and skin wrinkling in mice.

research Melanocytes and Vitiligo (and Hair Graying)

1 citations , January 2014 in “Elsevier eBooks”

Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.

research Functional Enhancers As Master Regulators of Tissue-Specific Gene Regulation and Cancer Development.

49 citations , March 2017 in “PubMed”

Enhancers and super-enhancers are key in controlling specific gene activity and can play a role in cancer development.

research Mapping of a novel locus for keratosis follicularis squamosa on chromosome 7p14.3–7p12.1

4 citations , December 2010 in “Journal of Dermatological Science”

A new gene location for Keratosis follicularis squamosa was found on chromosome 7p14.3-7p12.1.

research c-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

60 citations , February 2013 in “Cell reports”

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

research TGF-β family signaling in stem cells

132 citations , February 2013 in “Biochimica et Biophysica Acta (BBA) - General Subjects”

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

research TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition

82 citations , February 2017 in “Cold Spring Harbor Perspectives in Biology”

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Roles of <i>jumonji</i> and <i>jumonji</i> family genes in chromatin regulation and development

research Roles of jumonji and jumonji family genes in chromatin regulation and development

178 citations , May 2006 in “Developmental Dynamics”

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

Co-Expression Pattern of Artemis Serine 516 Phosphorylation with Indicators Involving in Differentiation, Proliferation and Apoptosis of Human Anagen Hair Follicles: An Immunofluorescence Double-Staining Study

research Co-Expression Pattern of Artemis Serine 516 Phosphorylation with Indicators Involving in Differentiation, Proliferation and Apoptosis of Human Anagen Hair Follicles: An Immunofluorescence Double-Staining Study

January 2023 in “Frontiers in bioscience”

Artemis protein may help control hair growth and health by influencing cell processes.

research Vitamin D and the skin: Physiology and pathophysiology

158 citations , August 2011 in “Reviews in endocrine and metabolic disorders”

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

research Identification of key genes induced by platelet-rich plasma in human dermal papilla cells using bioinformatics methods

16 citations , December 2016 in “Molecular Medicine Reports”

Platelet-rich plasma may help hair follicle cells grow by affecting certain genes and pathways.

research Fondation René Touraine

September 2013 in “Experimental Dermatology”

The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.

research Scratching the surface of skin development

788 citations , February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2

123 citations , February 2013 in “Stem cells”

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.

research Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro

31 citations , May 2019 in “Nature communications”

Single Blimp1+ cells can create functional sebaceous gland organoids in the lab.

Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

30 citations , September 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in vitro by Forming a Complex With Tcf4 and β-Catenin

research Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in vitro by Forming a Complex With Tcf4 and β-Catenin

13 citations , August 2020 in “Frontiers in Cell and Developmental Biology”

Twist1 helps maintain important features of cells crucial for hair growth by working with Tcf4 and β-catenin.

research The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity

January 2018 in “Stem cell biology and regenerative medicine”

ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.

research Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization

29 citations , October 2016 in “Cell death and differentiation”

ΔNp63α stops TAp73β from working in skin cancer by blocking its access to specific genes, not by directly interacting with it.

Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

research Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

81 citations , September 2005 in “The American journal of pathology”

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

research Adenovirus-Mediated Wnt5a Expression Inhibits the Telogen-To-Anagen Transition of Hair Follicles in Mice

19 citations , January 2013 in “International journal of medical sciences”

Increasing Wnt5a in mice skin delays hair growth but doesn't stop it.

research New Antifungal Agents and New Formulations Against Dermatophytes

113 citations , August 2016 in “Mycopathologia”

New topical antifungals and delivery systems are improving treatment for fungal skin infections, but patient education and prevention are key.

research A computationally inferred regulatory heart aging model including post-transcriptional regulations

1 citations , December 2016

Researchers created a model to understand heart aging, highlighting key genes and pathways, and suggesting miR-208a as a potential heart attack biomarker.

research TCDD-induced activation of aryl hydrocarbon receptor regulates the skin stem cell population

9 citations , March 2015 in “Medical hypotheses”

TCDD disrupts skin stem cells, causing skin issues like chloracne.

research A TP63 Mutation Causes Prominent Alopecia with Mild Ectodermal Dysplasia

2 citations , May 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

A TP63 gene mutation causes significant hair loss and mild skin, nail, and tooth abnormalities.

research Impaired Notch‐MKP‐1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology

112 citations , March 2013 in “Experimental dermatology”

Faulty Notch signalling may cause hair follicle changes and inflammation in hidradenitis suppurativa.

research Function of KLF4 in Stem Cell Biology

5 citations , August 2013 in “InTech eBooks”

KLF4 is important for maintaining stem cells and has potential in cancer treatment and wound healing.

research Targeting the Wnt pathways for therapies

112 citations , January 2014 in “Molecular and cellular therapies”

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.