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This study observed that mTORC1 signaling is activated and crucial for hair follicle regeneration and hair growth in irradiated mice, facilitating recovery within 96 hours without significant hair loss.

This study found that inhibiting the Mitochondrial Pyruvate Carrier in human hair follicles ex vivo activated the integrated stress response, affecting cell proliferation and metabolism.

This study observed that in hormone-starved prostate cancer cells, the androgen 5alpha-dihydrotestosterone rapidly induces matriptase activation and shedding, which involves androgen receptor signaling and requires both transcription and protein synthesis.

This study identified a novel phase of stem cell quiescence, GAlert, in mice, regulated by mTORC1, that primes stem cells for injury response.

This study found that inhibiting the Mitochondrial Pyruvate Carrier in human scalp hair follicles caused metabolic stress that halted cell proliferation and disrupted key signaling pathways, with these effects partially reversed by an integrated stress response inhibitor.

Immune cells boost stem cell activity in hairy moles, causing more hair growth.

Food deprivation increases MST enzyme in the brain, possibly affecting energy balance.

This article reports two cases where ovarian hyperthecosis caused hyperandrogenism in postmenopausal women, confirmed by imaging and resolved after bilateral oophorectomy.

This study found that Oncostatin M, via JAK-STAT5 signaling, keeps hair follicle stem cells inactive, and its removal leads to hair growth initiation in mice.

mTORC2 is crucial for healthy skin barrier by regulating lipids and filaggrin.

Alpha-MSH affects mitochondrial function, and MC1R mutations may increase skin aging.

This case report highlights the need for early diagnosis and treatment of ovarian hyperthecosis to enhance the quality of life and health outcomes for affected patients.

The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.

This case study describes two postmenopausal women with severe androgen excess symptoms, diagnosed with ovarian hyperthecosis and stromal hyperplasia, emphasizing the challenges in differentiating these benign conditions from androgen-secreting tumors and the importance of surgical and histopathological evaluation for correct diagnosis and management.

This review discusses the characteristics, diagnostic challenges, and management options for postmenopausal hyperandrogenism but reports no new clinical results; it highlights the importance of distinguishing potential androgen-producing tumors or hyperandrogenic disorders.

This review discusses the emerging role of AMT in fibrosis and suggests that targeting AMT could offer a novel approach to treatment; it reports no new clinical results.

This review highlights the role of matriptase in epithelial differentiation and cancer, noting that unregulated matriptase expression can enhance cancer progression in animal models, but reports no new experimental data.

This review discusses the role of matriptase and its inhibitor HAI-1 in epithelial homeostasis and cancer development, highlighting their imbalance's link to cancer progression without presenting new experimental results.

This study describes a functional disorder in the ovary, known as stromal hyperplasia, characterized by the proliferation of ovarian stroma and luteinization of stromal cells, which is linked to excessive androgen production and elevated testosterone levels.

This study found that TRPV4 activation induced massive exocytosis and cellular changes associated with ferroptosis in melanoma cells, highlighting a potential role for TRPV4 in mediating these processes.

This study suggests that Merkel cell polyomavirus T antigen-positive cells resembling Merkel cell carcinoma may originate from epithelial cells in human hair follicles, potentially informing future transgenic mouse models for this cancer.

This case report details a postmenopausal woman with increased libido, hirsutism, and spontaneous orgasms, noting elevated testosterone levels and enlarged ovaries.

Resident memory T cells and necroptosis may drive fibrosis in eosinophilic fasciitis and morphea.

This study describes a postmenopausal woman's diagnosis with ovarian hyperthecosis, confirmed by a GnRHa test normalizing testosterone, highlighting hormone therapy as a therapeutic option when surgery is not feasible.

This study found that minoxidil stimulates the Kir6.2/SUR2 potassium channel, leading to tumor growth arrest in an ovarian cancer xenograft model by disrupting mitochondrial function and inducing cell death.

This review discusses auxin's role in regulating plant growth through TOR activation and translation reinitiation but reports no new experimental findings.

This study found that HtrA2 inactivation in mnd2 mice is associated with delayed hair cycle phases and growth retardation of adipocytes, suggesting HtrA2's role in regulating adipogenesis-related hair growth.

This study presents two adolescent cases of ovarian hyperthecosis, a rare cause of severe hyperandrogenism, highlighting management strategies involving gonadotropin suppression and hormone replacement after excluding androgen-producing adrenal and ovarian tumors.

This case series observed that ovarian hyperthecosis can manifest with hyperandrogenism and insulin resistance in postmenopausal women, even when serum testosterone levels are below diagnostic thresholds, suggesting potential gaps in current diagnostic criteria.