Epidermal Mammalian Target of Rapamycin Complex 2 Controls Lipid Synthesis and Filaggrin Processing in Epidermal Barrier Formation

    August 2019 in “ Journal of Allergy and Clinical Immunology ”
    Xiaolei Ding, Sebastian Willenborg, Wilhelm Bloch … Sabine A. Eming
    Studysummary mTORC2 is crucial for healthy skin barrier by regulating lipids and filaggrin.
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    Research cited in this study 3

    1. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    2. Cystatin M/E Is a High Affinity Inhibitor of Cathepsin V and Cathepsin L by a Reactive Site Distinct from the Legumain-binding Site Journal of biological chemistry/˜The œJournal of biological chemistry · 2006
    3. Loss of Keratin 10 Is Accompanied by Increased Sebocyte Proliferation and Differentiation European journal of cell biology · 2004