Postmenopausal Hyperandrogenism

May 2021 in “ Climacteric ”

YOLDEMİR, AHMET TEVFİK

hyperandrogenism androgens terminal hair growth alopecia virilization androgen-producing tumors polycystic ovary syndrome Cushing syndrome testosterone hirsutism adrenal tumors ovarian androgen-secreting tumors hormone therapy PCOS Cushing's disease

TLDR Postmenopausal hyperandrogenism involves excess male hormones causing symptoms like hair growth and acne, and requires ruling out tumors and other disorders.

The document discussed postmenopausal hyperandrogenism, a condition characterized by excess androgens from the adrenal glands and/or ovaries, leading to symptoms like terminal hair growth, acne, alopecia, and virilization. It emphasized the importance of ruling out serious androgen-producing tumors and considering other hyperandrogenic disorders such as polycystic ovary syndrome and Cushing syndrome. Elevated testosterone levels were linked to health issues like hypercholesterolemia and cardiac disease. Ovarian androgen-secreting tumors were rare, diagnosed in 1-3 of 1000 hirsutism cases, while adrenal tumors were even less common. Diagnosis involved measuring various hormone levels and possibly MRI imaging. Medical management with hormone therapy was suggested for those unfit for surgery or with unidentified testosterone sources.

View this study on tandfonline.com →

Discuss this study in the Community →

Research cited in this study

15 / 15 results

research Clinical Case Seminar: Postmenopausal Androgen Excess - Challenges in Diagnostic Work-Up and Management of Ovarian Thecosis

20 citations , October 2017 in “Clinical Endocrinology”

The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.

Discriminating Between Virilizing Ovary Tumors and Ovary Hyperthecosis in Postmenopausal Women: Clinical Data, Hormonal Profiles, and Imaging Studies

research Discriminating Between Virilizing Ovary Tumors and Ovary Hyperthecosis in Postmenopausal Women: Clinical Data, Hormonal Profiles, and Imaging Studies

27 citations , April 2017 in “European journal of endocrinology”

The research found that MRI and certain hormone levels can help tell apart ovarian tumors from hyperthecosis in postmenopausal women, but tissue analysis is still needed for a definite diagnosis.

research Management of Endocrine Disease: Hyperandrogenism After Menopause

84 citations , September 2014 in “European journal of endocrinology”

Doctors should check for serious tumor causes of high androgen levels in postmenopausal women and more research is needed on this condition.

research Therapy of Endocrine Disease: Treatment of Hirsutism in Polycystic Ovary Syndrome

40 citations , November 2013 in “European journal of endocrinology”

Effective hirsutism treatment for women with PCOS should be personalized and may include lifestyle changes and medication.

research Hyperandrogenism in Post-Menopausal Women: A Diagnosis Challenge

9 citations , November 2013 in “Gynecological Endocrinology”

A woman had high testosterone due to an ovarian issue, which was fixed with surgery.

No Metabolic Impact of Surgical Normalization of Hyperandrogenism in Postmenopausal Women with Ovarian Androgen-Secreting Tumors

research No Metabolic Impact of Surgical Normalization of Hyperandrogenism in Postmenopausal Women with Ovarian Androgen-Secreting Tumors

17 citations , May 2012 in “Clinical Endocrinology”

Surgery to lower high testosterone in postmenopausal women with certain ovarian tumors doesn't significantly affect their metabolism.

research Gonadotropin-Releasing Hormone Agonist Treatment in Postmenopausal Women with Hyperandrogenism of Ovarian Origin

36 citations , May 2011 in “The Journal of Clinical Endocrinology & Metabolism”

Treatment with a hormone agonist can reduce excess male hormones in postmenopausal women without surgery.

research How Should Postmenopausal Androgen Excess Be Evaluated?

63 citations , March 2011 in “Clinical Endocrinology”

Evaluate postmenopausal women with high androgen levels using medical history, physical exams, lab tests, and imaging to manage health risks.

Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

research Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

815 citations , April 2010 in “The Journal of Clinical Endocrinology & Metabolism”

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

research Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline

502 citations , February 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Treat significant hirsutism with medication and hair removal; use birth control pills first, adding antiandrogens if needed.

The Investigation and Management of Severe Hyperandrogenism Pre- and Postmenopause: Non-Tumor Disease Is Strongly Associated with Metabolic Syndrome and Typically Responds to Insulin-Sensitization with Metformin

research The Investigation and Management of Severe Hyperandrogenism Pre- and Postmenopause: Non-Tumor Disease Is Strongly Associated with Metabolic Syndrome and Typically Responds to Insulin-Sensitization with Metformin

14 citations , January 2008 in “Gynecological Endocrinology”

High levels of male hormones in women without tumors are linked to metabolic problems and can be treated with metformin.

research A Case of Virilizing Brenner Tumor in a Postmenopausal Woman With Stromal Androgenic Activity

6 citations , June 2006 in “International Journal of Gynecological Pathology”

A postmenopausal woman's hormone imbalance and symptoms improved after removing benign ovarian tumors.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS)

4025 citations , December 2003 in “Human Reproduction”

The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.

research Androgenetic Alopecia in a Postmenopausal Woman Due to Ovarian Hyperthecosis

17 citations , February 2003 in “Australasian Journal of Dermatology”

Hair loss in postmenopausal woman caused by ovarian issue.

Related Research

1 / 1 results

research Clinical, Laboratory, and Radiological Diagnosis of Hyperandrogenism

January 2022

Hyperandrogenism is diagnosed using clinical signs, lab tests, and imaging.