Hyperandrogenism in Post-Menopausal Women: A Diagnosis Challenge

    November 2013 in “ Gynecological Endocrinology ”
    Marta Tutzer, Irina Winnykamien, Jhery Davila Guardia, Camil Castelo‐Branco
    TLDR A woman had high testosterone due to an ovarian issue, which was fixed with surgery.
    A 79-year-old woman exhibited increased hair growth on her chin and upper lip, with elevated serum testosterone levels, suggesting a testosterone-secreting tumor. Imaging identified a nodular formation in the left adrenal gland and a hydrosalpinx in the right ovary. Differential diagnosis considered an androgen-producing ovarian tumor or an adrenal tumor. Suppression tests indicated an ovarian source, leading to surgery that confirmed Leydig cell hyperplasia. Post-surgery, testosterone levels normalized, and symptoms regressed.
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