Hyperandrogenism in Post-Menopausal Women: A Diagnosis Challenge
November 2013
in “
Gynecological Endocrinology
”
Studysummary This case study identified a probable pure testosterone-secreting ovarian tumor in a woman with increased facial hair and elevated testosterone levels, confirmed by histological examination as Leydig cells hyperplasia, which normalized testosterone and symptoms post-surgery.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
A 79-year-old woman exhibited increased hair growth on her chin and upper lip, with elevated serum testosterone levels, suggesting a testosterone-secreting tumor. Imaging identified a nodular formation in the left adrenal gland and a hydrosalpinx in the right ovary. Differential diagnosis considered an androgen-producing ovarian tumor or an adrenal tumor. Suppression tests indicated an ovarian source, leading to surgery that confirmed Leydig cell hyperplasia. Post-surgery, testosterone levels normalized, and symptoms regressed.
