Ovarian Hyperthecosis in Adolescent Females: Two Case Reports and a Review of the Literature

Ovarian hyperthecosis (OHT) is a rare cause of severe hyperandrogenism in adolescents. This paper presents two cases: Patient A, a 13-year-old with androphonia and hirsutism, had elevated testosterone (8.3 nmol/L) and enlarged ovaries, treated with GnRH agonist and spironolactone; and Patient B, a 14-year-old with secondary amenorrhoea, androphonia, hirsutism, and androgenetic alopecia, had higher testosterone (12 nmol/L) and numerous ovarian follicles, managed with GnRH agonist and oral contraceptives. The study concludes that OHT should be considered in pre-menopausal women with severe hyperandrogenism, emphasizing gonadotropin suppression and hormone replacement for management.