Ovarian Hyperthecosis Coexisting with an Incidental Adrenal Lesion: Challenges in the Diagnostic Approach

    June 2017 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”
    G Giuffrida, Salvatore Giovinazzo, Rosaria Certo, Francesco Trimarchi, Salvatore Cannavò, Rosaria M. Ruggeri
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    TLDR Using GnRHa agonists helps diagnose and treat ovarian hyperthecosis when surgery isn't possible.
    The document from June 2017 discussed a case of a 62-year-old woman with ovarian hyperthecosis, a common cause of hyperandrogenism in postmenopausal women, who also had an incidental adrenal mass. The patient had high testosterone and androstenedione levels and had been experiencing androgenetic alopecia and hirsutism for several years. A GnRHa test confirmed the diagnosis of ovarian hyperthecosis by showing gonadotropin suppression and testosterone normalization. The study concluded that the use of GnRHa agonists was crucial in excluding an androgen-secreting neoplasia and limiting the use of ovarian veins catheterization. The agonists were also considered a valid therapeutic option when surgery was contraindicated or could not be performed.
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