Postmenopausal Hyperandrogenism Associated With Synchronous Ovarian Brenner Tumor, Bilateral Leydig Cell Tumor, and Adrenal Mass

    March 2024 in “ Curēus
    Michael Salim, Sandhyarani Dasaraju, Britt Erickson, Mahmoud Khalifa, Lynn A. Burmeister
    Image of study
    TLDR A thorough diagnostic process and teamwork are crucial for managing complex hyperandrogenism in postmenopausal women.
    This case study describes a 66-year-old postmenopausal woman with hyperandrogenism, virilization, and an adrenal incidentaloma, who was found to have rare ovarian tumors: bilateral Leydig cell tumors and a Brenner tumor. Elevated testosterone and androstenedione levels, along with incomplete suppression in a dexamethasone test, pointed to the ovaries as the androgen source. Despite normal-appearing ovaries on imaging, laparoscopic bilateral salpingo-oophorectomy (BSO) was performed, confirming the tumors. Postoperatively, her alopecia improved, and testosterone levels normalized. This case underscores the importance of thorough diagnostic processes and interdisciplinary collaboration in managing complex hyperandrogenism cases in postmenopausal women.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 7 results

      community Proposed new pathogenesis model for androgenetic alopecia (AGA)

      in Research/Science  8 upvotes 1 year ago
      The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  35 upvotes 5 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community Spironolactine Update: 2 months (34, Female)

      in Female  23 upvotes 8 years ago
      A female user's experience using Spironolactone to treat Female Pattern Hair Loss (FPHL) and Androgenic Alopecia, as well as discussing the effectiveness of the drug at different dosages.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 1 year ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

    Related Research

    2 / 2 results