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GlossaryLeydig Cell Tumor

rare testicular tumor from testosterone-producing Leydig cells

A Leydig Cell Tumor is a rare type of tumor that originates from the Leydig cells, which are found in the testes and are responsible for producing testosterone. These tumors can occur in both children and adults and may cause symptoms such as testicular swelling, pain, or hormonal imbalances. While most Leydig Cell Tumors are benign, a small percentage can be malignant and may require surgical removal and further treatment.

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research Hirsutism Due to Bilateral Leydig Cell Tumors

April 2020 in “Journal of the Endocrine Society”

A woman's severe hirsutism was caused by Leydig cell tumors in her ovaries, which improved after surgery.

research Sertoli-Leydig Cell Tumors: Hormonal Profile After Dynamic Test with GnRH Analogue Triptorelin Represents a Useful Tool to Evaluate Tumoral Hyperandrogenism

5 citations, October 2014 in “Gynecological Endocrinology”

Triptorelin helps evaluate hormone production in Sertoli-Leydig cell tumors.

research Ovarian Vein Sampling, and Serum and Urine Testosterone Monitoring in Ovarian Leydig Cell Tumors: A Report of Two Cases

2 citations, November 2019 in “Case reports in women's health”

Ovarian vein sampling helped diagnose rare ovarian tumors causing high testosterone, and surgery to remove the tumors lowered the testosterone levels.

research Diagnostic Pitfalls in Ovarian Androgen-Secreting (Leydig Cell) Tumors: Case Series

5 citations, November 2018 in “Journal of Obstetrics and Gynaecology”

Ovarian Leydig cell tumors are hard to diagnose with just advanced imaging; expert ultrasound and clinical evaluation are essential.

research Occult Ovarian Leydig Cell Tumor: When Laboratory Tells More Than Imaging

5 citations, October 2013 in “Endocrine”

Blood tests can detect ovarian Leydig cell tumors when scans don't, and surgery can confirm and treat these tumors.

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community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 4 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community FtM: "Aggressive Regemin - Recovery From Norwood-6.5" Minoxodil/Estradiol valerate/Spironolactone. (What will happen in the worst case if CIS male go this way for a year?)

in Progress Pictures 53 upvotes 3 years ago

User "Ant1pal" shares progress pictures of hair regrowth using Minoxidil, Estradiol valerate, and Spironolactone. Users discuss potential side effects and the possibility of localizing estrogen to hair follicles for better treatment.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.