Postmenopausal Hyperandrogenism Due to Ovarian Hyperthecosis

January 2023 in “ Case Reports in Obstetrics and Gynecology ”

Laryssa Santos Metzker, Luyanne Azevedo Cabral Ferreira, Julia Caroliny Nogueira Borges, Mariana Furieri Guzzo, Rodrigo Neves Ferreira, Lucas Luciano Rocha Silva, Rodrigo Monico Cavedo, Antônio Chambô Filho

hyperandrogenism ovarian hyperthecosis androgenetic alopecia hirsutism testosterone bilateral salpingo-oophorectomy androgenic alopecia hair loss high testosterone ovary removal surgery

TLDR A woman's high testosterone levels and related symptoms improved after ovary removal surgery.

The document is a case report of a 64-year-old postmenopausal woman who suffered from severe hyperandrogenism due to ovarian hyperthecosis, a disorder more common in postmenopausal women. This condition caused her to experience androgenetic alopecia, progressive hirsutism, and significantly high testosterone levels (483.4 ng/dL). After a bilateral salpingo-oophorectomy, her testosterone levels dropped to 13.4 ng/dL and there was a slight improvement in her alopecia. However, some androgenic signs persisted. The report emphasizes the need for further studies to improve early diagnosis and treatment of ovarian hyperthecosis to enhance patients' quality of life and minimize complications.

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Research cited in this study

2 / 2 results

research Management of Endocrine Disease: Hyperandrogenism After Menopause

84 citations, September 2014 in “European journal of endocrinology”

Doctors should check for serious tumor causes of high androgen levels in postmenopausal women and more research is needed on this condition.

research How Should Postmenopausal Androgen Excess Be Evaluated?

63 citations, March 2011 in “Clinical Endocrinology”

Evaluate postmenopausal women with high androgen levels using medical history, physical exams, lab tests, and imaging to manage health risks.

Related Research

2 / 2 results

research Postmenopausal Hyperandrogenism in a Patient With an Adrenal Adenoma: How Should We Approach It?

1 citations, July 2015 in “AACE clinical case reports”

Removing both ovaries treated the woman's excess male hormone symptoms.

research Androgen Dependence of Hirsutism, Acne, and Alopecia in Women

105 citations, January 2009 in “Medicine”

Hirsutism is more linked to high androgen levels than acne or hair loss, and a mix of hormonal tests is best for diagnosis; certain treatments can reduce symptoms.

Postmenopausal Hyperandrogenism Due to Ovarian Hyperthecosis

Research cited in this study

research Management of Endocrine Disease: Hyperandrogenism After Menopause

research How Should Postmenopausal Androgen Excess Be Evaluated?

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