Diagnostic Challenges in Ovarian Hyperthecosis: Clinical Presentation with Subdiagnostic Testosterone Levels

    January 2022 in “ Case Reports in Endocrinology ”
    S. Shah, Callie Torres, Naser Eddin Gharaibeh
    TLDR Ovarian hyperthecosis can cause symptoms even with normal testosterone levels, and surgery can improve these symptoms.
    This case series discussed two postmenopausal women with symptoms of hyperandrogenism and metabolic abnormalities due to ovarian hyperthecosis, despite having normal imaging and subdiagnostic testosterone levels. Both underwent bilateral oophorectomy based on clinical suspicion, and histological examination confirmed the diagnosis. Post-surgery, both patients showed improvement in symptoms and insulin resistance. The study highlighted the need for further research into the disease's pathophysiology and reconsideration of diagnostic testosterone thresholds, emphasizing the importance of considering ovarian hyperthecosis in similar clinical presentations.
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