Matrix-Degrading Type II Transmembrane Serine Protease Matriptase: Its Role in Cancer Development and Malignancy

October 2006

Ming‐Shyue Lee

TLDR Matriptase imbalance contributes to cancer development and spread.

Matriptase, a type II transmembrane serine protease derived from epithelial cells, played a crucial role in epithelial homeostasis and was implicated in cancer development and progression. It was regulated by its inhibitor, HAI-1, which controlled its expression, trafficking, and activity. In animal models, matriptase was essential for postnatal survival, epidermal barrier function, and hair follicle development. Deregulation of matriptase led to carcinogenesis and malignant transformation, with imbalances in matriptase and HAI-1 expression being linked to cancer stages. This malfunction significantly contributed to cancer development and metastasis.

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research Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis

100 citations , May 2006 in “American Journal Of Pathology”

Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.

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research Matriptase Activation and Shedding with HAI-1 Induced by Steroid Sex Hormones in Human Prostate Cancer Cells, but Not in Breast Cancer Cells

56 citations , February 2006 in “American journal of physiology. Cell physiology”

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research Matriptase: Potent Proteolysis on the Cell Surface

165 citations , January 2006 in “Molecular Medicine”

Matriptase is crucial for skin, hair, and immune cell health, and its imbalance can lead to cancer.

research Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis

324 citations , May 2002 in “Oncogene”