TLDR Matriptase imbalance contributes to cancer development and spread.
Matriptase, a type II transmembrane serine protease derived from epithelial cells, played a crucial role in epithelial homeostasis and was implicated in cancer development and progression. It was regulated by its inhibitor, HAI-1, which controlled its expression, trafficking, and activity. In animal models, matriptase was essential for postnatal survival, epidermal barrier function, and hair follicle development. Deregulation of matriptase led to carcinogenesis and malignant transformation, with imbalances in matriptase and HAI-1 expression being linked to cancer stages. This malfunction significantly contributed to cancer development and metastasis.
100 citations
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May 2006 in “American Journal Of Pathology” Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.
56 citations
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February 2006 in “American journal of physiology. Cell physiology” Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
165 citations
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January 2006 in “Molecular Medicine” Matriptase is crucial for skin, hair, and immune cell health, and its imbalance can lead to cancer.
324 citations
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May 2002 in “Oncogene”
137 citations
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October 2009 in “The American journal of pathology” Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.
100 citations
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May 2006 in “American Journal Of Pathology” Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.
165 citations
,
January 2006 in “Molecular Medicine” Matriptase is crucial for skin, hair, and immune cell health, and its imbalance can lead to cancer.
56 citations
,
February 2006 in “American journal of physiology. Cell physiology” Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
9 citations
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September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.