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This study found that human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) improved hair growth and follicle structure in male rats with androgenic alopecia, achieving better results and longer-lasting effects compared to minoxidil treatment, with no observed side effects.

This review found that vesicle-based therapies, including mammalian MSC-derived and plant-derived vesicles, consistently promote wound healing in preclinical models of thermal injury and may offer a safer alternative to live cell transplants.

This paper proposes a model integrating regulatory T cells and mesenchymal stem/stromal cells to enhance understanding of peripheral immune tolerance, suggesting their combined roles in immune regulation, autoimmunity pathophysiology, and potential MSC-based therapies.

In a mouse model, this study demonstrated that a microneedle patch system using keratin and integrated with MSC-derived exosomes and UK5099 promoted hair regrowth more efficiently than traditional delivery methods.

In this study, only a subset of proposed biomarkers universally responded to priming in mesenchymal stromal cells, suggesting limited utility for standardized potency assays across different MSC types and conditions.

This study found that adipose-derived mesenchymal stromal cell secretome, particularly when preconditioned with IFNγ, significantly influences cell motility and anti-inflammatory responses, enhancing its potential as a regenerative therapy.

This review examines mesenchymal stem cell therapy as a promising alternative for end-stage liver disease, discussing completed clinical trials and highlighting challenges that must be addressed before clinical application.

In this review, researchers summarized findings from clinical studies on mesenchymal stem cells for diabetes treatment, noting their potential but also highlighting challenges like small sample sizes and the need for standardization in preparation and delivery methods.

This study explored how high glucose concentrations impact mesenchymal stromal cell survival in diabetic environments, highlighting mitochondrial factors as potential targets for enhancing cell viability.

This review discusses the use of mesenchymal stem cells in treating diseases, particularly focusing on their application in pediatric Graft-versus-Host Disease, with most studies reporting safety and effectiveness in animals.

This study found that a newly created biomimetic microneedle platform effectively expedited wound repair in diabetic animal models by reducing inflammation, enhancing angiogenesis, and promoting skin regeneration through targeted drug delivery and immune response modification.

This study found that placenta-derived mesenchymal stem cells overexpressing PRL-1 inhibited adipogenesis in orbital fibroblasts from Graves’ ophthalmopathy patients by modulating specific signaling pathways, suggesting a potential therapeutic strategy.

This study identified a comprehensive global landscape of stemness-related gene clusters in adipose-derived mesenchymal stem cells, revealing that stemness was highest in cells from young donors and lowest in those from elderly donors.

This study identified a distinct CD49fhigh mesenchymal stem cell subpopulation in the dermis that supports hair follicle development and maintenance via Notch signaling activation.

In this case series, mesenchymal stem cell exosomes were reported to improve hair length, density, pigmentation, and cuticle layer recovery in three patients with acquired trichorrhexis nodosa, suggesting potential as a therapeutic approach for this hair condition.

This study found that mesenchymal stem cells showed potential to differentiate into hair follicle stem cells when induced by the supernatant of cultured hair follicles in vitro.

This article provides an overview of mesenchymal stem cells, highlighting their extraction methods, differentiation potential, and applications in regenerative medicine, but reports no new clinical findings.

This review discusses the potential of mesenchymal stem cells and their secretome as promising therapeutic tools for systemic lupus erythematosus but reports no new clinical results.

In this study, the authors observed that the combined treatment group showed a significant increase in inflammatory cell density and a higher maximum tensile breaking force in tendon repair by the end of the second month.

In this review, researchers discussed the potential of mesenchymal stem cells and their exosomes as a promising therapy for burn injuries, emphasizing their role in inflammation regulation, tissue regeneration, and overcoming challenges in clinical translation, but noting obstacles in standardization and quality control.

This study found that in a fluconazole-induced alopecia-like rat model, a 14-day treatment with hypoxia-induced mesenchymal stem cell exosomes significantly increased TGF-β and PDGF levels, which may improve hair growth and suggests a potential therapeutic strategy for alopecia and other inflammation-related skin disorders.

This study found that administering mesenchymal stem cells to UV-exposed mice reduced melanin levels, although the decrease was not statistically significant.

This study found that bone marrow mesenchymal stem cells promoted faster wound healing and thicker epidermis in rabbit skin wounds, suggesting they can differentiate into epidermal cells and aid regeneration.

This study found that hair follicle-derived dermal stem cells and bone marrow mesenchymal stem cells have similar growth, differentiation capabilities, and surface marker expressions, suggesting hair follicles could be accessible sources for mesenchymal stem cells.

In this study, human bone marrow mesenchymal stem cell-derived exosomes significantly accelerated cutaneous wound healing in rats by modulating the TGF-β/Smad signaling pathway.

This review discusses the potential of mesenchymal stem cells from the oral cavity for tissue regeneration in oral and maxillofacial surgery but reports no new clinical results.

This review discusses the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles and modern technologies like 3D bioprinting but reports no new clinical results.

This review examines various methods to enhance the functionality and therapeutic potential of mesenchymal stem cells for clinical use, highlighting both advancements and ongoing limitations, without presenting new clinical results.

This study found that exosomes from different mesenchymal stem cell sources had distinct effects on immune cell functions and varied microRNA expression profiles compared to their original cells.

In this study, severe hair loss occurred in PKC epsilon transgenic mice treated with DFMO during skin tumor prevention, highlighting a link between polyamine biosynthesis, hair follicle maintenance, and metastasis suppression.