Methods and Limitations of Augmenting Mesenchymal Stem Cells for Therapeutic Applications

    October 2022 in “ Advances in Wound Care ”
    Carlos Theodore Huerta, Yulexi Y. Ortiz, Zhaojun Liu, Omaida C. Velázquez
    Studysummary This review examines various methods to enhance the functionality and therapeutic potential of mesenchymal stem cells for clinical use, highlighting both advancements and ongoing limitations, without presenting new clinical results.
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    Research cited in this study 16

    1. Systematic Review: The Platelet-Rich Plasma Use in Female Androgenetic Alopecia as Effective Autologous Treatment of Regenerative Plastic Surgery Journal of Plastic Reconstructive and Aesthetic Surgery · 2021
    2. AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing Expert Opinion on Biological Therapy · 2021
    3. Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma, and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects International Journal of Molecular Sciences · 2021
    4. Systematic Review: The Potential Implications of Different Platelet-Rich Plasma Concentrations in Regenerative Medicine for Tissue Repair International Journal of Molecular Sciences · 2020
    5. Systematic Review: Allogenic Use of Stromal Vascular Fraction and Decellularized Extracellular Matrices as Advanced Therapy Medicinal Products in Tissue Regeneration International Journal of Molecular Sciences · 2020
    6. Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy International Journal of Molecular Sciences · 2020
    7. Autologous Activated Platelet-Rich Plasma (AA-PRP) and Non-Activated (A-PRP) in Hair Growth: A Retrospective, Blinded, Randomized Evaluation in Androgenetic Alopecia Expert Opinion on Biological Therapy · 2020
    8. Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation International Journal of Molecular Sciences · 2020
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    10. Impact of Different Preparation Methods to Obtain Human Adipose-Derived Stromal Vascular Fraction Cells and Human Adipose-Derived Mesenchymal Stem Cells: Enzymatic Digestion Versus Mechanical Centrifugation International Journal of Molecular Sciences · 2019
    11. Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia International Journal of Molecular Sciences · 2019
    12. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    13. Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss Stem cell investigation · 2017
    14. Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems International Journal of Molecular Sciences · 2017
    15. The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial Stem Cells Translational Medicine · 2015
    16. The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation BioMed Research International · 2014