Beyond Wound Closure: Translational Opportunities and Barriers of Mesenchymal Stem Cells and Their Extracellular Vesicles in Burn Management

    May 2026 in “ Frontiers in Cell and Developmental Biology ”
    Yue Wang, Junyan Li, Liyuan Zhang … 徐尚福
    Studysummary In this review, researchers discussed the potential of mesenchymal stem cells and their exosomes as a promising therapy for burn injuries, emphasizing their role in inflammation regulation, tissue regeneration, and overcoming challenges in clinical translation, but noting obstacles in standardization and quality control.
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    Research cited in this study 14

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    2. Enhancing Hair Regrowth Using Rapamycin-Primed Mesenchymal Stem Cell-Derived Exosomes Theranostics · 2025
    3. Exosome Laden Sprayable Thermo-Sensitive Polysaccharide-Based Hydrogel for Enhanced Burn Wound Healing International Journal of Biological Macromolecules · 2024
    4. Mesenchymal Stem Cells Pretreated With Collagen Promote Skin Wound-Healing International journal of molecular sciences · 2023
    5. Stem Cell-Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing Stem cell research & therapy · 2023
    6. Biofabrication of Human Skin with Its Appendages Advanced Healthcare Materials · 2022
    7. Dendritic Epidermal T Cells Secreting Exosomes Promote the Proliferation of Epidermal Stem Cells to Enhance Wound Re-Epithelialization Stem Cell Research & Therapy · 2022
    8. MSCs and Their Exosomes: A Rapidly Evolving Approach in the Context of Cutaneous Wound Therapy Stem Cell Research & Therapy · 2021
    9. Stem Cell Therapy for Burns: The Story So Far Biologics · 2021
    10. Therapeutic Effect of Mesenchymal Stem Cells on Histopathological, Immunohistochemical, and Molecular Analysis in Second-Degree Burn Model Stem Cell Research & Therapy · 2021
    11. 3D Bioprinting of Integral ADSCs-NO Hydrogel Scaffolds to Promote Severe Burn Wound Healing Regenerative Biomaterials · 2021
    12. Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation International Journal of Molecular Sciences · 2021
    13. Wound Healing: Cellular Mechanisms and Pathological Outcomes Open Biology · 2020
    14. Efficacy Assessment of Mesenchymal Stem Cell Transplantation for Burn Wounds in Animals: A Systematic Review Stem Cell Research & Therapy · 2020