The Effects of a Combination Treatment with Mesenchymal Stem Cell and Platelet Rich Plasma on Tendon Healing: An Experimental Study

January 2021 in “ TURKISH JOURNAL OF MEDICAL SCIENCES ”

İlker Uyar, Zeynep Altuntaş, Sıddıka Fındık, Mehmet Emin Cem Yıldırım, Serhat Yarar, Murat Aktan, Ahmet Avcı

Studysummary In this study, the authors observed that the combined treatment group showed a significant increase in inflammatory cell density and a higher maximum tensile breaking force in tendon repair by the end of the second month.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This experimental study investigated the effects of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) on tendon healing in 80 rats. The study divided the rats into eight groups, with different combinations of MSCs and PRP injected into the repaired Achilles tendons. The results showed that the combination of MSCs and PRP significantly increased tendon strength, as evidenced by a higher mean maximum breaking force at the end of the second month compared to the first month (p = 0.0008). Additionally, inflammatory cell density was highest in the combined treatment group. The study concluded that the combination therapy of MSCs and PRP could positively contribute to tendon healing post-surgery.

View this study on doi.org →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma for Treating Androgenic Alopecia

24 citations , November 2017 in “Aesthetic Plastic Surgery”

In this study, researchers found that homologous PRP (h-PRP) significantly increased hair density more than both nonactivated (n-PRP) and activated (a-PRP) autologous PRP in patients with androgenetic alopecia, suggesting h-PRP as a potentially more effective treatment option for hair loss.