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Metreleptin treatment significantly improved metabolic health in a boy with congenital generalized lipodystrophy.

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

New drugs are improving treatment for hormone-related diseases in small pets.

Tadalafil is effective for treating urinary symptoms in men with BPH.

The African spiny mouse can fully regenerate its muscle without scarring, unlike the common house mouse.

Using rodents for research shows that health problems in the womb can cause diseases later in life.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

High levels of the protein Flightless I worsen ulcerative colitis symptoms in mice.

Mais estudos são necessários para garantir a eficácia e qualidade dos tratamentos de alopecia com plantas medicinais.

Low selenium levels can extend lifespan but worsen health issues.

The study found key factors in the cause of hidradenitis suppurativa, its link to other diseases, and identified existing drugs that could potentially treat it.

Vitamin D is essential for bone health and may reduce risks of several diseases.

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

Patients with RASopathies are at risk for autoimmune disorders and should be routinely screened.

A 10-month-old boy with a rare combination of genetic conditions has severe immune deficiency and treatment challenges.

Finasteride treatment for three years changes certain polyamine levels in the blood but not in urine.

Fibroblast state switching is crucial for skin healing and development.

Five preservatives may disrupt hormone function and need more health and environmental risk assessment.

PCOS in teen girls should be managed with lifestyle changes and sometimes medication to improve symptoms and health.

Most dogs with adrenal-dependent hypercortisolism had normal blood pressure after one year of treatment or surgery.

Integrin β1 is crucial for liver structure and function, preventing fibrosis.

Ishige sinicola extract may help prevent muscle atrophy through its antioxidant and anti-inflammatory effects.

Korean Red Ginseng saponins may protect skin from inflammation and darkening caused by air pollution.

ATP-sensitive K+ channel subunits, particularly Sur2A, play a significant role in various cancers.

The conclusion is that obesity should be managed with a slow, balanced approach to diet and exercise, with medication and surgery as additional options, and education and access to care are important.

Testosterone can help premenopausal and postmenopausal women with low sexual desire, but its long-term safety is unclear and it's not widely approved for this use.

The conclusion is that women under 35 should start fertility checks after 12 months of trying to conceive, women over 35 after 6 months, and women over 40 should start immediately. The checks should include ovulation status, reproductive tract structure, and male partner's semen evaluation.

IL-3 worsens lupus nephritis and blocking it improves kidney health.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

Minoxidil and ranolazine together can reduce the spread of certain breast cancer cells.