Flightless I Exacerbation of Inflammatory Responses Contributes to Increased Colonic Damage in a Mouse Model of Dextran Sulfate Sodium-Induced Ulcerative Colitis

    September 2019 in “ Scientific Reports ”
    Zlatko Kopecki, Gink N. Yang, Susan A. Treloar … Allison J. Cowin
    Studysummary In this study, high levels of the protein Flii in mice were associated with worsened symptoms and inflammation in ulcerative colitis, suggesting Flii may inhibit mucosal healing.
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    Research cited in this study 3

    1. Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair Advances in Wound Care · 2019
    2. Flightless I Expression Enhances Murine Claw Regeneration Following Digit Amputation Journal of Investigative Dermatology · 2016
    3. Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model Journal of Investigative Dermatology · 2010