Flightless I Exacerbation of Inflammatory Responses Contributes to Increased Colonic Damage in a Mouse Model of Dextran Sulfate Sodium-Induced Ulcerative Colitis

The document presents a study that explored the impact of Flightless I (Flii), an immuno-modulatory protein, on ulcerative colitis (UC) in a mouse model. The study found that mice with high levels of Flii experienced more severe UC symptoms, including increased inflammation and colonic damage, while mice with low Flii levels had reduced disease severity. The study involved 8 mice per genotype and demonstrated that Flii overexpression disrupts Wnt/β-catenin signaling, which is essential for colonic crypt regeneration. These findings suggest that Flii exacerbates UC and that targeting Flii could be a potential therapeutic approach to improve UC outcomes.