Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats

January 2021 in “ Oxidative Medicine and Cellular Longevity ”

Lin Zhou, Fengjuan Yan, Rui Jiang, Jing Liu, Limin Cai, Yongchen Wang

Nrf-2 hair-follicle mesenchymal stem cells HF-MSCs dextran sulfate sodium ulcerative colitis intestinal stem cell inflammatory factors anti-inflammatory factors disease activity index hair-follicle stem cells DSS UC intestinal stem cells inflammatory markers anti-inflammatory markers disease activity

Studysummary In this study, Nrf-2-expressing hair follicle mesenchymal stem cells showed the most significant therapeutic effect in a rat model of ulcerative colitis, suggesting a new potential treatment for the disease.

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research The Angiogenic Potential of Mesenchymal Stem Cells from the Hair Follicle Outer Root Sheath

8 citations , February 2021 in “Journal of Clinical Medicine”

This study found that mesenchymal stem cells sourced from hair follicle outer root sheath showed higher differentiation efficiency and angiogenic potential for vascular graft applications compared to adipose-derived stem cells.