Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats
January 2021
in “
Oxidative Medicine and Cellular Longevity
”
Nrf-2 hair-follicle mesenchymal stem cells HF-MSCs dextran sulfate sodium ulcerative colitis intestinal stem cell inflammatory factors anti-inflammatory factors disease activity index hair-follicle stem cells DSS UC intestinal stem cells inflammatory markers anti-inflammatory markers disease activity
TLDR Nrf-2-modified stem cells from hair follicles significantly improve ulcerative colitis in rats.
The study investigated the therapeutic effects of Nrf-2-modified hair-follicle mesenchymal stem cells (HF-MSCs) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in rats. The rats were divided into five groups, including a healthy control and UC model rats treated with normal saline, Nrf-2, HF-MSCs, or Nrf-2-expressing HF-MSCs. Results showed that the Nrf-2-expressing HF-MSCs group exhibited the most significant improvement in terms of intestinal stem cell expression, inflammatory and anti-inflammatory factors, and disease activity index scores. This suggested that Nrf-2-expressing HF-MSCs could be a promising new treatment for UC.
