Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats
January 2021
in “
Oxidative Medicine and Cellular Longevity
”
Nrf-2 hair-follicle mesenchymal stem cells HF-MSCs dextran sulfate sodium ulcerative colitis intestinal stem cell inflammatory factors anti-inflammatory factors disease activity index hair-follicle stem cells DSS UC intestinal stem cells inflammatory markers anti-inflammatory markers disease activity
TLDR Nrf-2-modified stem cells from hair follicles significantly improve ulcerative colitis in rats.
The study demonstrated that Nrf-2-modified hair follicle mesenchymal stem cells (HF-MSCs) effectively treated dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in rats. It involved 5 groups of rats, including a healthy control and 4 UC model groups treated with different substances. The group treated with Nrf-2-expressing HF-MSCs showed the most significant improvement, with the lowest disease activity index scores and reduced inflammation. The treatment promoted intestinal stem cell proliferation and reduced oxidative stress, indicated by increased anti-inflammatory cytokines and decreased inflammatory markers. The study concluded that Nrf-2-HF-MSCs could be a promising therapeutic option for UC, as they repaired damaged intestinal tissue and modulated inflammatory responses.
