Flightless I Expression Enhances Murine Claw Regeneration Following Digit Amputation

    September 2016 in “ Journal of Investigative Dermatology ”
    Xanthe L. Strudwick, James M. Waters, Allison J. Cowin
    Studysummary In this study, Flii overexpression in mice enhanced fingertip regeneration and nail formation after both distal and proximal amputations, suggesting a role in digit and hair follicle regeneration possibly involving Wnt signaling.
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    Research cited in this study 5

    1. Cytoskeletal Regulation of Dermal Regeneration Cells · 2012
    2. Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model Journal of Investigative Dermatology · 2010
    3. Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing BMC Cell Biology · 2006
    4. Expression of Hair Keratins in the Adult Nail Unit: An Immunohistochemical Analysis of Onychogenesis in the Proximal Nail Fold, Matrix, and Nail Bed British Journal of Dermatology · 2004
    5. Keratin Expression in the Normal Nail Unit: Markers of Regional Differentiation British Journal of Dermatology · 2000