Skin Inflammation Activates Intestinal Stromal Fibroblasts and Promotes Colitis

    October 2021 in “ Journal of Clinical Investigation ”
    Tatsuya Dokoshi, Jason S. Seidman, Kellen Cavagnero … Richard L. Gallo
    Studysummary This study suggests that inflammation in the skin can exacerbate intestinal inflammation in inflammatory bowel diseases by activating fibroblasts in the colon through hyaluronan fragments released during skin inflammation.
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    Research cited in this study 2

    1. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    2. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007