IL-3 Contributes to Development of Lupus Nephritis in MRL/Ipr Mice

    July 2015 in “ Kidney International ”
    Karl Renner, Fabian Johannes Hermann, Kathrin Schmidbauer, Yvonne Talke, Manuel R. Gómez, Gabriela Schiechl, Jens Schlossmann, Hilke Brühl, Hans‐Joachim Anders, Matthias Mack
    TLDR IL-3 worsens lupus nephritis and blocking it improves kidney health.
    The study investigated the role of IL-3 in lupus nephritis using MRL/lpr mice, a model for human SLE. Researchers found that IL-3 levels increased during disease progression and that administering IL-3 worsened the condition. Blocking IL-3 with a monoclonal antibody significantly improved kidney damage, reduced glomerular leukocyte infiltration, IgG deposition, and renal fibrosis. The study concluded that IL-3 played a crucial role in the pathogenesis of lupus nephritis, suggesting that IL-3 blockade could be a potential therapeutic strategy for treating this condition.
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