Anti-Invasive Effects of Minoxidil on Human Breast Cancer Cells: Combination with Ranolazine

    May 2022 in “ Clinical & Experimental Metastasis ”
    Shiwen Qiu, Scott E. Fraser, Wayne Pires, Mustafa B.A. Djamgoz
    TLDR Minoxidil and ranolazine together can reduce the spread of certain breast cancer cells.
    The study investigated the anti-invasive effects of minoxidil (MIN) and ranolazine (RAN) on triple-negative human breast cancer cell lines MDA-MB-231 and MDA-MB-468. Both drugs significantly reduced cell invasion in a dose-dependent manner without affecting cell viability or proliferation. Combining MIN and RAN produced additive anti-invasive effects, particularly under hypoxic conditions, and was effective at lower concentrations, reducing potential adverse effects. Electrophysiological analysis showed that MIN inhibited VGSC activation. The findings suggest that MIN and RAN, alone or in combination, could be repurposed as anti-metastatic agents for managing TNBC invasiveness.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 1000+ results

      community 2 months minoxidil, vitamins and micro needling

      in Minoxidil  459 upvotes 2 days ago
      The conversation discusses using minoxidil, vitamins, and microneedling for hair loss treatment over two months. Users inquire about the specific vitamins used and the ease of microneedling.

      community Minoxidil: Is 2x any better than 1x daily?

      in Minoxidil  7 upvotes 3 days ago
      Using minoxidil twice daily may offer around 20% better regrowth compared to once daily, but once daily is still effective, especially with dermastamping. The user also uses dutasteride and finasteride daily, and is considering increasing minoxidil application despite concerns about cost and potential shedding.

      community Almost 6 months in minoxidil / finastride

      in Minoxidil  141 upvotes 3 days ago
      The user experienced significant hair regrowth using 2.5 mg minoxidil and 1 mg finasteride prescribed by a dermatologist, with no negative side effects reported. The progress has inspired others to try similar treatments for hair loss.

      community Can I use trichosol minoxidil before sleep?

      in Minoxidil  3 upvotes 1 week ago
      The user applies 2ml of a lotion containing 5% minoxidil, 0.3% finasteride, hydrocortisone butyrate, and cetirizine before bed, but it leaves a residue on the scalp. Another user suggests reducing the amount to 1ml, as 2ml results in a high finasteride dosage.

    Related Research

    1 / 1 results