Anti-Invasive Effects of Minoxidil on Human Breast Cancer Cells: Combination with Ranolazine

    Shiwen Qiu, Scott E. Fraser, Wayne Pires, Mustafa B.A. Djamgoz
    TLDR Minoxidil and ranolazine together can reduce the spread of certain breast cancer cells.
    The study investigated the anti-invasive effects of minoxidil (MIN) and ranolazine (RAN) on triple-negative human breast cancer cell lines MDA-MB-231 and MDA-MB-468. Both drugs significantly reduced cell invasion in a dose-dependent manner without affecting cell viability or proliferation. Combining MIN and RAN produced additive anti-invasive effects, particularly under hypoxic conditions, and was effective at lower concentrations, reducing potential adverse effects. Electrophysiological analysis showed that MIN inhibited VGSC activation. The findings suggest that MIN and RAN, alone or in combination, could be repurposed as anti-metastatic agents for managing TNBC invasiveness.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 1000+ results

      community Oral Minoxidil Secret Very important

      in Minoxidil  230 upvotes 6 days ago
      Oral minoxidil can cause side effects like shortness of breath and constipation, which may be reduced by taking it in the morning. Some users experience no side effects, while others switch to topical treatments or adjust their dosage and timing to manage symptoms.

      community How to get oral minoxidil in EU?

      in Minoxidil  10 upvotes 1 week ago
      A user from France is seeking ways to obtain oral minoxidil in the EU without a prescription, as local doctors are hesitant to prescribe it. Suggestions include visiting Spain for a prescription, ordering online, or consulting doctors in other EU countries like Portugal.

      community Use minoxidil & finasteride. It works.

      in Minoxidil  555 upvotes 1 week ago
      Minoxidil and finasteride effectively improve hairlines and reduce balding, though some users report side effects like reduced libido. Consistent use over 1-2 years leads to significant hair regrowth, with some users also using skincare and biotin for added benefits.

    Related Research

    1 / 1 results