Anti-Invasive Effects of Minoxidil on Human Breast Cancer Cells: Combination with Ranolazine

    Shiwen Qiu, Scott E. Fraser, Wayne Pires, Mustafa B.A. Djamgoz
    Studysummary This study found that minoxidil and ranolazine, individually and in combination, reduced cellular invasiveness in hypoxic triple-negative breast cancer cell lines, suggesting potential anti-metastatic effects at clinically relevant doses.
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    Research cited in this study 7

    1. Repurposing Kir6/SUR2 Channel Activator Minoxidil to Arrest Growth of Gynecologic Cancers Frontiers in pharmacology · 2020
    2. Minoxidil Is a Potential Neuroprotective Drug for Paclitaxel-Induced Peripheral Neuropathy Scientific Reports · 2017
    3. Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism ˜The œjournal of pharmacology and experimental therapeutics/˜The œJournal of pharmacology and experimental therapeutics · 2016
    4. Glibenclamide Inhibits Cell Growth by Inducing G0/G1 Arrest in the Human Breast Cancer Cell Line MDA-MB-231 BMC Pharmacology and Toxicology · 2013
    5. Minoxidil Opens Mitochondrial KATP Channels and Confers Cardioprotection British Journal of Pharmacology · 2004
    6. Electrophysiological Mechanisms of Minoxidil Sulfate-Induced Vasodilation of Rabbit Portal Vein Circulation Research · 1989
    7. Biochemical Mechanisms by Which Minoxidil Sulfate Influences Mammalian Cells Dermatology · 1987

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