Pharmacological Approaches in Managing Symptomatic Relief of Benign Prostatic Hyperplasia: A Comprehensive Review

    December 2023 in “ Curēus ”
    Collyn O’Quin, Kathryn White, John R. Campbell, Sarah Myers, Shilpadevi Patil, Debbie Chandler, Shahab Ahmadzadeh, Giustino Varrassi, Sahar Shekoohi, Alan D. Kaye
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    TLDR Tadalafil is effective for treating urinary symptoms in men with BPH.
    Benign Prostatic Hyperplasia (BPH) is a common condition in aging men that causes lower urinary tract symptoms (LUTS) and can lead to severe complications. This comprehensive review evaluates various pharmacological treatments for BPH, including alpha-1 antagonists, 5-alpha reductase inhibitors, anticholinergics, and combination therapies. Recent research highlights the effectiveness of phosphodiesterase 5 (PDE5) inhibitors, such as Tadalafil and Sildenafil, in treating LUTS associated with BPH, with Tadalafil showing significant improvement as a monotherapy. The review also discusses the debated efficacy of herbal remedies like saw palmetto, noting inconsistencies in recent trials. The findings aim to assist healthcare professionals in making informed treatment decisions to improve patient outcomes.
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