Pharmacological Approaches in Managing Symptomatic Relief of Benign Prostatic Hyperplasia: A Comprehensive Review

December 2023 in “ Curēus ”

Collyn O’Quin, Kathryn White, John R. Campbell, Sarah Myers, Shilpadevi Patil, Debbie Chandler, Shahab Ahmadzadeh, Giustino Varrassi, Sahar Shekoohi, Alan D. Kaye

5-alpha reductase inhibitors alpha-1 antagonists anticholinergics phosphodiesterase 5 inhibitors Tadalafil Sildenafil saw palmetto Cialis Viagra

Studysummary This literature review identified that phosphodiesterase 5 inhibitors, such as Tadalafil, are highly effective in improving lower urinary tract symptoms associated with benign prostatic hyperplasia, while the efficacy of saw palmetto remains inconsistent.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Benign Prostatic Hyperplasia (BPH) is a common condition in aging men that causes lower urinary tract symptoms (LUTS) and can lead to severe complications. This comprehensive review evaluates various pharmacological treatments for BPH, including alpha-1 antagonists, 5-alpha reductase inhibitors, anticholinergics, and combination therapies. Recent research highlights the effectiveness of phosphodiesterase 5 (PDE5) inhibitors, such as Tadalafil and Sildenafil, in treating LUTS associated with BPH, with Tadalafil showing significant improvement as a monotherapy. The review also discusses the debated efficacy of herbal remedies like saw palmetto, noting inconsistencies in recent trials. The findings aim to assist healthcare professionals in making informed treatment decisions to improve patient outcomes.

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Research cited in this study

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research What Do We Know About Phytotherapy of Benign Prostatic Hyperplasia?

67 citations , February 2015 in “Life Sciences”

This review discusses phytotherapy options for managing benign prostatic hyperplasia, noting some herbal agents show promise in trials for mild-moderate symptoms but more evidence is needed for others.

research A Comparison of Varying Alpha-Blockers and Other Pharmacotherapy Options for Lower Urinary Tract Symptoms

52 citations , January 2005 in “PubMed”

This study concluded that alpha(1)-adrenoceptor antagonists are more effective than finasteride in the short term for reducing symptoms of lower urinary tract symptoms associated with benign prostatic hyperplasia.