A Comparison of Varying Alpha-Blockers and Other Pharmacotherapy Options for Lower Urinary Tract Symptoms

    January 2005 in “ PubMed ”
    Christopher R. Chapple
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    Studysummary This study concluded that alpha(1)-adrenoceptor antagonists are more effective than finasteride in the short term for reducing symptoms of lower urinary tract symptoms associated with benign prostatic hyperplasia.
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    The document reviewed the effectiveness of alpha(1)-adrenoceptor antagonists and 5alpha-reductase inhibitors in treating lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia. Alpha(1)-adrenoceptor antagonists were found to be effective for all patients, regardless of prostate size, and were superior to placebo in improving urinary flow and reducing symptoms. They were more effective than finasteride in the short term for reducing symptom scores. Common side effects included dizziness and postural hypotension, with alfuzosin affecting blood pressure more than tamsulosin, which was well tolerated with minimal blood pressure effects.
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