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    Glossary Macrophage Infiltration

    immune cells moving into tissue, often due to injury

    Macrophage infiltration refers to the process where macrophages, a type of immune cell, move into a specific tissue or area in the body, often in response to injury or infection. These cells help to clear out debris, pathogens, and dead cells, and can also signal other immune responses. In the context of hair and alopecia, macrophage infiltration can influence hair follicle health and potentially contribute to hair loss or regrowth.

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    1. Loss of PIKFyve Kinase Function Driven by Platelet Factor 4 Promoter Results in Platelet Lysosomal Storage Defects and Infiltration of Multiple Organs with Vacuolated Macrophages Blood · 2011
    2. Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages Cell reports · 2022 · 6 citations
    3. Implanted hair-follicle-associated pluripotent (HAP) stem cells differentiating to keratinocytes, macrophages and endothelial cells accelerated cutaneous wound closure and suppressed scar formation in a mouse model Research Square (Research Square) · 2022
    4. 877 Loss of UBE2N in keratinocytes leads to skin inflammation and immune infiltration through IRAK1/4-mediated processes 2023
    5. Human Macrophages Preferentially Infiltrate the Superficial Adipose Tissue International Journal of Molecular Sciences · 2018 · 18 citations
    6. Alterations of collagen type 1, skin fibroblasts, and macrophages in the scalp following the treatment of 1550‐nm erbium glass fractional laser for androgenetic alopecia Journal of Cosmetic Dermatology · 2021
    7. Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege International Journal of Cosmetic Science · 2024
    8. Investigation of hub genes and immune infiltration in androgenetic alopecia using bioinformatics analysis Annals of Translational Medicine · 2022
    9. The effect of human hair keratin hydrogel on early cellular response to sciatic nerve injury in a rat model Biomaterials · 2013 · 105 citations
    10. Extracellular vesicles from adipose-derived stem cells ameliorate ultraviolet B-induced skin photoaging by attenuating reactive oxygen species production and inflammation Stem Cell Research & Therapy · 2020 · 90 citations
    11. Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-mediated Root Sheath Disruption in Advance of Overt Hair Loss Veterinary pathology · 2003 · 37 citations
    12. Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia PLOS ONE · 2012 · 22 citations
    13. Adipose stem cells from type 2 diabetic mice exhibit therapeutic potential in wound healing Stem Cell Research & Therapy · 2020 · 21 citations
    14. Stress, Hair Growth Control, and the Neuro-Endocrine-Immune Connection Allergo Journal · 2000 · 7 citations
    15. The protective role of FTY720 in promoting survival of allograft fat in mice The Kaohsiung Journal of Medical Sciences · 2022 · 2 citations
    16. Adipose Stem Cells from Type 2 Diabetic Mice Exhibit Therapeutic Potential in Wound Healing Research Square (Research Square) · 2020 · 2 citations
    17. Non‐thymoma‐associated exfoliative dermatitis in a European shorthair cat: A case report Veterinary Medicine and Science · 2021 · 1 citations
    18. 0874 TGF-β signaling-mediated wound healing is required for hair follicle neogenesis Journal of Investigative Dermatology · 2025
    19. Adipose Stem Cells from Type 2 Diabetic Mice Exhibit Therapeutic Potential in Wound Healing Research Square (Research Square) · 2020
    20. Nematic Fibrin Fibers Enabling Vascularized Thrombus Implants Facilitate Scarless Cutaneous Wound Healing Advanced materials · 2023 · 8 citations
    21. 584 Dandruff is associated with perturbations of hair follicle immune privilege, and the infundibular and epidermal immune microenvironment Journal of Investigative Dermatology · 2022
    22. 0150 Single-cell and spatial transcriptome profiling reveals innate-adaptive crosstalk in alopecia areata Journal of Investigative Dermatology · 2025
    23. Photoaging Skin Therapy with PRP and ADSC: A Comparative Study Stem Cells International · 2020 · 27 citations
    24. Alopecia Areata Springer eBooks · 2017 · 1 citations
    25. 259 Immunohistochemical insight into the association between the collapse of immune privilege in the sweat gland and syringotropic immune cell infiltrates in collagen diseases Journal of Investigative Dermatology · 2017
    26. 137 Loss of myeloid Mcpip1 suppresses hair growth and development of epidermal papilloma of the skin 2023
    27. 730 M2 macrophages promote wound induced hair neogenesis through the production of growth factors 2016
    28. Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages Annals of the Rheumatic Diseases · 2014 · 36 citations
    29. Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart PLOS ONE · 2015 · 44 citations
    30. Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression 2016 · 25 citations