Adipose Stem Cells from Type 2 Diabetic Mice Exhibit Therapeutic Potential in Wound Healing

March 2020 in “ Research Square (Research Square) ”

Yongfa Sun, Lili Song, Yong Zhang, Hongjun Wang, Dong Xiao

adipose-derived mesenchymal stem cells ASCs type 2 diabetic mice wound healing HGF VEGF TGF-β skin fibroblast proliferation inflammation macrophage infiltration fat-derived stem cells diabetic mice hepatocyte growth factor vascular endothelial growth factor transforming growth factor beta skin cell growth inflammation reduction immune cell infiltration

TLDR Type 2 diabetic stem cells can still help heal wounds effectively.

Adipose-derived mesenchymal stem cells (ASCs) from type 2 diabetic (T2D) mice were found to be slightly less effective in promoting wound healing compared to control ASCs, as they secreted lower levels of key growth factors like HGF, VEGF, and TGF-β. Despite this, T2D ASCs still demonstrated comparable therapeutic effects in wound healing, including promoting skin fibroblast proliferation and migration, and reducing inflammation and macrophage infiltration. The study concluded that while T2D ASCs were marginally inferior, they still held significant potential for therapeutic use in wound healing.

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